| http://purl.uniprot.org/citations/11823439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11823439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11823439 | http://www.w3.org/2000/01/rdf-schema#comment | "We report that the cyclophilin USA-CyP is part of distinct complexes with two spliceosomal proteins and is involved in both steps of pre-mRNA splicing. The splicing factors hPrp18 and hPrp4 have a short region of homology that defines a high affinity binding site for USA-CyP in each protein. USA-CyP forms separate, stable complexes with hPrp18 and hPrp4 in which the active site of the cyclophilin is exposed. The cyclophilin inhibitor cyclosporin A slows pre-mRNA splicing in vitro, and we show that its inhibition of the second step of splicing is caused by blocking the action of USA-CyP within its complex with hPrp18. Cyclosporin A also slows splicing in vivo, and we show that this slowing results specifically from inhibition of USA-CyP. Our results lead to a model in which USA-CyP is carried into the spliceosome in complexes with hPrp4 and hPrp18, and USA-CyP acts during splicing within these complexes. These results provide an example of the function of a cyclophilin in a complex process and provide insight into the mechanisms of action of cyclophilins."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/21.3.470"xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/21.3.470"xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/author | "Lee E.J."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/author | "Lee E.J."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/author | "Misteli T."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/author | "Misteli T."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/author | "Horowitz D.S."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/author | "Horowitz D.S."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/author | "Mabon S.A."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/author | "Mabon S.A."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/pages | "470-480"xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/pages | "470-480"xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/title | "A cyclophilin functions in pre-mRNA splicing."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/title | "A cyclophilin functions in pre-mRNA splicing."xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/11823439 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11823439 |
| http://purl.uniprot.org/citations/11823439 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11823439 |