| http://purl.uniprot.org/citations/11823513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11823513 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice infected with Citrobacter rodentium represent an excellent model in which to examine immune defenses against an attaching-effacing enteric bacterial pathogen. Colonic tissue from mice infected with C. rodentium harbors increased transcripts for IL-12 and IFN-gamma and displays mucosal pathology compared with uninfected controls. In this study, the role of IL-12 and IFN-gamma in host defense and mucosal injury during C. rodentium infection was examined using gene knockout mice. IL-12p40(-/-) and IFN-gamma(-/-) mice were significantly more susceptible to mucosal and gut-derived systemic C. rodentium infection. In particular, a proportion of IL-12p40(-/-) mice died during infection. Analysis of the gut mucosa of IL-12p40(-/-) mice revealed an influx of CD4(+) T cells and a local IFN-gamma response. Infected IL-12p40(-/-) and IFN-gamma(-/-) mice also mounted anti-Citrobacter serum and gut-associated IgA responses and strongly expressed inducible NO synthase (iNOS) in mucosal tissue, despite diminished serum nitrite/nitrate levels. However, iNOS does not detectably contribute to host defense against C. rodentium, as iNOS(-/-) mice were not more susceptible to infection. However, C57BL/6 mice infected with C. rodentium up-regulated expression of the mouse beta-defensin (mBD)-1 and mBD-3 in colonic tissue. In contrast, expression of mBD-3, but not mBD-1, was significantly attenuated during infection of IL-12- and IFN-gamma-deficient mice, suggesting mBD-3 may contribute to host defense. These studies are among the first to examine mechanisms of host resistance to an attaching-effacing pathogen and show an important role for IL-12 and IFN-gamma in limiting bacterial infection of the colonic epithelium."xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.168.4.1804"xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/author | "Dougan G."xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/author | "Frankel G."xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/author | "Simmons C.P."xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/author | "MacDonald T.T."xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/author | "Clare S."xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/author | "Goncalves N.S."xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/author | "Neves B."xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/author | "Bajaj-Elliott M."xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/author | "Ghaem-Maghami M."xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/pages | "1804-1812"xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/title | "Impaired resistance and enhanced pathology during infection with a noninvasive, attaching-effacing enteric bacterial pathogen, Citrobacter rodentium, in mice lacking IL-12 or IFN-gamma."xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://purl.uniprot.org/core/volume | "168"xsd:string |
| http://purl.uniprot.org/citations/11823513 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11823513 |
| http://purl.uniprot.org/citations/11823513 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11823513 |
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| http://purl.uniprot.org/uniprot/#_D3YC69-mappedCitation-11823513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11823513 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-11823513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11823513 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-11823513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11823513 |
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| http://purl.uniprot.org/uniprot/#_C4NUM1-mappedCitation-11823513 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11823513 |