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| http://purl.uniprot.org/citations/11830665 | http://www.w3.org/2000/01/rdf-schema#comment | "Although the biochemical targets of most drugs are known, the biological consequences of their actions are typically less well understood. In this study, we have used two whole-genome technologies in Saccharomyces cerevisiae to determine the cellular impact of the proteasome inhibitor PS-341. By combining population genomics, the screening of a comprehensive panel of bar-coded mutant strains, and transcript profiling, we have identified the genes and pathways most affected by proteasome inhibition. Many of these function in regulated protein degradation or a subset of mitotic activities. In addition, we identified Rpn4p as the transcription factor most responsible for the cell's ability to compensate for proteasome inhibition. Used together, these complementary technologies provide a general and powerful means to elucidate the cellular ramifications of drug treatment."xsd:string |
| http://purl.uniprot.org/citations/11830665 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.032516399"xsd:string |
| http://purl.uniprot.org/citations/11830665 | http://purl.uniprot.org/core/author | "Bulawa C.E."xsd:string |
| http://purl.uniprot.org/citations/11830665 | http://purl.uniprot.org/core/author | "Sadis S."xsd:string |
| http://purl.uniprot.org/citations/11830665 | http://purl.uniprot.org/core/author | "Blackman R.K."xsd:string |
| http://purl.uniprot.org/citations/11830665 | http://purl.uniprot.org/core/author | "Fleming J.A."xsd:string |
| http://purl.uniprot.org/citations/11830665 | http://purl.uniprot.org/core/author | "Lightcap E.S."xsd:string |
| http://purl.uniprot.org/citations/11830665 | http://purl.uniprot.org/core/author | "Thoroddsen V."xsd:string |
| http://purl.uniprot.org/citations/11830665 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11830665 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/11830665 | http://purl.uniprot.org/core/pages | "1461-1466"xsd:string |
| http://purl.uniprot.org/citations/11830665 | http://purl.uniprot.org/core/title | "Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341."xsd:string |
| http://purl.uniprot.org/citations/11830665 | http://purl.uniprot.org/core/volume | "99"xsd:string |
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