| http://purl.uniprot.org/citations/11832213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11832213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11832213 | http://www.w3.org/2000/01/rdf-schema#comment | "The ADF (actin-depolymerizing factor)/cofilin family is a stimulus-responsive mediator of actin dynamics. In contrast to the mechanisms of inactivation of ADF/cofilin by kinases such as LIM-kinase 1 (LIMK1), much less is known about its reactivation through dephosphorylation. Here we report Slingshot (SSH), a family of phosphatases that have the property of F actin binding. In Drosophila, loss of ssh function dramatically increased levels of both F actin and phospho-cofilin (P cofilin) and disorganized epidermal cell morphogenesis. In mammalian cells, human SSH homologs (hSSHs) suppressed LIMK1-induced actin reorganization. Furthermore, SSH and the hSSHs dephosphorylated P cofilin in cultured cells and in cell-free assays. Our results strongly suggest that the SSH family plays a pivotal role in actin dynamics by reactivating ADF/cofilin in vivo."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(01)00638-9"xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(01)00638-9"xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/author | "Mizuno K."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/author | "Mizuno K."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/author | "Nagata-Ohashi K."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/author | "Nagata-Ohashi K."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/author | "Niwa R."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/author | "Niwa R."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/author | "Takeichi M."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/author | "Takeichi M."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/author | "Uemura T."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/author | "Uemura T."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/pages | "233-246"xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/pages | "233-246"xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/title | "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/title | "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin."xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/11832213 | http://purl.uniprot.org/core/volume | "108"xsd:string |