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http://purl.uniprot.org/citations/11834724http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11834724http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11834724http://www.w3.org/2000/01/rdf-schema#comment"The Xrcc2 and Rad51D/Rad51L3 proteins, which belong to the Rad51 paralogs, are required for homologous recombinational repair (HRR) in vertebrates. The Xrcc2 and Rad51D/Rad51L3 genes, whose products interact with each other, have essential roles in ensuring normal embryonic development. In the present study, we coexpressed the human Xrcc2 and Rad51D/Rad51L3 proteins (Xrcc2 and Rad51D, respectively) in Escherichia coli, and purified the Xrcc2*Rad51D complex to homogeneity. The Xrcc2 small middle dotRad51D complex catalyzed homologous pairing between single-stranded and double-stranded DNA, similar to the function of the Xrcc3*Rad51C complex, which is another complex of the Rad51 paralogs. An electron microscopic analysis showed that Xrcc2*Rad51D formed a multimeric ring structure in the absence of DNA. In the presence of ssDNA, Xrcc2*Rad51D formed a filamentous structure, which is commonly observed among the human homologous pairing proteins, Rad51, Rad52, and Xrcc3*Rad51C."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.org/dc/terms/identifier"doi:10.1074/jbc.m105719200"xsd:string
http://purl.uniprot.org/citations/11834724http://purl.org/dc/terms/identifier"doi:10.1074/jbc.m105719200"xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Ikawa S."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Ikawa S."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Shibata T."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Shibata T."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Yokoyama S."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Yokoyama S."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Kagawa W."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Kagawa W."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Kurumizaka H."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Kurumizaka H."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Nakada M."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Nakada M."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Yamazoe M."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Yamazoe M."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Enomoto R."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Enomoto R."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Kinebuchi T."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/author"Kinebuchi T."xsd:string
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11834724http://purl.uniprot.org/core/date"2002"xsd:gYear