| http://purl.uniprot.org/citations/11836526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11836526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11836526 | http://www.w3.org/2000/01/rdf-schema#comment | "In epithelial cells, tyrosine kinases induce the tyrosine phosphorylation and ubiquitination of the E-cadherin complex, which induces endocytosis of E-cadherin. With a modified yeast 2-hybrid system, we isolated Hakai, an E-cadherin binding protein, which we have identified as an E3 ubiquitin-ligase. Hakai contains SH2, RING, zinc-finger and proline-rich domains, and interacts with E-cadherin in a tyrosine phosphorylation-dependent manner, inducing ubiquitination of the E-cadherin complex. Expression of Hakai in epithelial cells disrupts cell--cell contacts and enhances endocytosis of E-cadherin and cell motility. Through dynamic recycling of E-cadherin, Hakai can thus modulate cell adhesion, and could participate in the regulation of epithelial--mesenchymal transitions in development or metastasis."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb758"xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb758"xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Fujita Y."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Fujita Y."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Krause G."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Krause G."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Sommer T."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Sommer T."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Behrens J."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Behrens J."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Birchmeier W."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Birchmeier W."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Scheffner M."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Scheffner M."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Molina Leddy H.E."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Molina Leddy H.E."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Zechner D."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/author | "Zechner D."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/11836526 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |