| http://purl.uniprot.org/citations/11840505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11840505 | http://www.w3.org/2000/01/rdf-schema#comment | "In the present study, we sought to identify genetic variation in the metabotropic glutamate receptor 3 (GRM3) gene, which has been mapped to chromosome 7q21.1-q21.2 [Scherer et al., 1996] and might contribute to genetic predisposition to schizophrenia and/or bipolar affective disorder. Using single-strand conformation analysis (SSCA), we screened the complete coding sequence as well as adjacent splice sites of the GRM3 gene in a sample of 46 bipolar affective and 46 schizophrenic patients. We detected three sequence variants: a rare C/T substitution at nucleotide position +885 (T209T), a C/T substitution at nucleotide position +2130 (Y624Y), and a more common C/T substitution at nucleotide position +1131 (A291A). The occurrence of the +1131C/T variant was investigated in a sample of bipolar affective patients (n=283), schizophrenic patients (n=265), and ethnically matched controls (n=227). We observed a significant overrepresentation of the +1131T allele in schizophrenic patients when compared to controls (P=0.0022). This finding was followed up in an independent sample of schizophrenic patients (n=288) and controls (n=162) and 128 schizophrenic trios but could not be confirmed. It is therefore unlikely that this variant plays a major role in predisposing to schizophrenia and/or bipolar affective disorder at least in the German population."xsd:string |
| http://purl.uniprot.org/citations/11840505 | http://purl.org/dc/terms/identifier | "doi:10.1002/ajmg.1624"xsd:string |
| http://purl.uniprot.org/citations/11840505 | http://purl.uniprot.org/core/author | "Propping P."xsd:string |
| http://purl.uniprot.org/citations/11840505 | http://purl.uniprot.org/core/author | "Cichon S."xsd:string |
| http://purl.uniprot.org/citations/11840505 | http://purl.uniprot.org/core/author | "Nothen M."xsd:string |
| http://purl.uniprot.org/citations/11840505 | http://purl.uniprot.org/core/author | "Marti S.B."xsd:string |
| http://purl.uniprot.org/citations/11840505 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11840505 | http://purl.uniprot.org/core/name | "Am J Med Genet"xsd:string |
| http://purl.uniprot.org/citations/11840505 | http://purl.uniprot.org/core/pages | "46-50"xsd:string |
| http://purl.uniprot.org/citations/11840505 | http://purl.uniprot.org/core/title | "Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population."xsd:string |
| http://purl.uniprot.org/citations/11840505 | http://purl.uniprot.org/core/volume | "114"xsd:string |
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