| http://purl.uniprot.org/citations/11842132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11842132 | http://www.w3.org/2000/01/rdf-schema#comment | "We employed quantitative trait locus (QTL) mapping in a backcross between gallstone-susceptible SWR/J and gallstone-resistant AKR/J inbred mice to identify additional susceptibility loci for cholesterol gallstone formation. After 12 wk of feeding the mice a lithogenic diet, we phenotyped 330 backcross progeny for gallstones, gallbladder mucin accumulation, liver weight, and body weight. Marker-based regression analysis revealed significant single QTLs associated with gallstone formation on chromosome 9 and the liver weight/body weight ratio on chromosomes 5 and X. A search for gene pairs detected significant gene-gene interactions for mucin accumulation between loci on chromosomes 5 and 11 and suggestive gene-gene interactions linked to gallstone formation between the QTL on chromosome 9 and loci on chromosomes 6 and 15. These findings uncover new QTLs for cholesterol gallstones, reveal independent loci for mucin accumulation, and demonstrate the importance of considering gene-gene interactions in cholesterol cholelithiasis. According to standard nomenclature, the gallstone QTL on chromosome 9 is named Lith5."xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.org/dc/terms/identifier | "doi:10.1152/physiolgenomics.00097.2001"xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/author | "Li R."xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/author | "Lammert F."xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/author | "Paigen B."xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/author | "Carey M.C."xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/author | "Churchill G.A."xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/author | "Wittenburg H."xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/author | "Bouchard G."xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/author | "Wang D.Q."xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/name | "Physiol Genomics"xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/pages | "67-77"xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/title | "Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice."xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/11842132 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11842132 |
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