| http://purl.uniprot.org/citations/11843843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11843843 | http://www.w3.org/2000/01/rdf-schema#comment | "There is mounting evidence to suggest that T-cell-mediated suppression of haemopoiesis is a pathogenetic mechanism in three bone marrow failure syndromes: aplastic anaemia (AA), paroxysmal nocturnal haemoglobinuria (PNH) and myelodysplasia (MDS). T-cell microclones can be detected by sensitive polymerase chain reaction (PCR)-based methods in all three disorders. Recently, larger clonal populations of T-cell large granular lymphocytes (T-LGLs) have been observed in some patients with AA and MDS. Here, we report the development of a large clonal T-LGL population in a patient with bona fide PNH. In this patient, we defined part of the sequence of the T-cell receptor (TCR) beta-chain gene, and we have shown that the large T-LGL population emerged from a background of multiple smaller T-cell clones. Thus, T-LGL clones in AA, MDS and PNH probably expand as a result of antigenic stimulation. It is postulated that the antigen driving clonal T-cell proliferations in these disorders exists on haemopoietic stem cells."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1365-2141.2001.03172.x"xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/author | "Luzzatto L."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/author | "Ladanyi M."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/author | "Nafa K."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/author | "Rosenfeld C.S."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/author | "Karadimitris A."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/author | "Thertulien R."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/author | "Roberts I.A."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/author | "Araten D.J."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/author | "Notaro R."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/author | "Stevens A.E."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/date | "2001"xsd:gYear |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/name | "Br J Haematol"xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/pages | "1010-1014"xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/title | "Association of clonal T-cell large granular lymphocyte disease and paroxysmal nocturnal haemoglobinuria (PNH): further evidence for a pathogenetic link between T cells, aplastic anaemia and PNH."xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/11843843 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11843843 |
| http://purl.uniprot.org/citations/11843843 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11843843 |
| http://purl.uniprot.org/uniprot/#_A0A2K4Z9P3-mappedCitation-11843843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11843843 |
| http://purl.uniprot.org/uniprot/#_A0A2K4Z9P4-mappedCitation-11843843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11843843 |
| http://purl.uniprot.org/uniprot/#_A0A2K4Z9P5-mappedCitation-11843843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11843843 |
| http://purl.uniprot.org/uniprot/#_A0A2K4Z9P6-mappedCitation-11843843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11843843 |