| http://purl.uniprot.org/citations/11845213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11845213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11845213 | http://www.w3.org/2000/01/rdf-schema#comment | "Repression of gene transcription by nuclear receptors is mediated by interactions with co-repressor proteins such as SMRT and N-CoR, which in turn recruit histone deacetylases to the chromatin. Aberrant interactions between nuclear receptors and co-repressors contribute towards acute promyelocytic leukaemia and thyroid hormone resistance syndrome. The binding of co-repressors to nuclear receptors occurs in the unliganded state, and can be stabilized by antagonists. Here we report the crystal structure of a ternary complex containing the peroxisome proliferator-activated receptor-alpha ligand-binding domain bound to the antagonist GW6471 and a SMRT co-repressor motif. In this structure, the co-repressor motif adopts a three-turn alpha-helix that prevents the carboxy-terminal activation helix (AF-2) of the receptor from assuming the active conformation. Binding of the co-repressor motif is further reinforced by the antagonist, which blocks the AF-2 helix from adopting the active position. Biochemical analyses and structure-based mutagenesis indicate that this mode of co-repressor binding is highly conserved across nuclear receptors."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.org/dc/terms/identifier | "doi:10.1038/415813a"xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.org/dc/terms/identifier | "doi:10.1038/415813a"xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Xu H.E."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Xu H.E."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Moore J.T."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Moore J.T."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Lambert M.H."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Lambert M.H."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Stanley T.B."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Stanley T.B."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Nolte R.T."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Nolte R.T."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Willson T.M."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Willson T.M."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Stimmel J.B."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Stimmel J.B."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Kliewer S.A."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Kliewer S.A."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "McKee D.D."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "McKee D.D."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Montana V.G."xsd:string |
| http://purl.uniprot.org/citations/11845213 | http://purl.uniprot.org/core/author | "Montana V.G."xsd:string |