http://purl.uniprot.org/citations/11846974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11846974 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/11846974 | http://www.w3.org/2000/01/rdf-schema#comment | "Numerous evidence has demonstrated the involvement in growth control of interferon (IFN) regulatory factor-1 (IRF-1), which shows tumor suppressor activity. IRF-1 is a well-studied member of the IRF transcription factors that reveals functional diversity in the regulation of cellular response by activating expression of a diverse set of target genes, depending on the cell type and on the specific stimuli. IRF-1 gene rearrangements may be a crucial point in the pathogenesis of some cancer types. Furthermore, different aspects of the tumor suppressor function of IRF-1 may be explained, at least in part, by the observations that IRF-1 is a regulator of cell cycle and apoptosis and that its inactivation accelerates cell transformation. Studies on gene knockout mice contributed greatly to the clarification of these multiple IRF-1 functions. We summarize our current knowledge of the antigrowth effect of IRF-1, focusing also on a more general involvement of IRF-1 in mediating negative regulation of cell growth induced by numerous cytokines and other biologic response modifiers."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.org/dc/terms/identifier | "doi:10.1089/107999002753452647"xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.org/dc/terms/identifier | "doi:10.1089/107999002753452647"xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/author | "Romeo G."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/author | "Romeo G."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/author | "Affabris E."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/author | "Affabris E."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/author | "Percario Z.A."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/author | "Percario Z.A."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/author | "Chiantore M.V."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/author | "Chiantore M.V."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/author | "Fiorucci G."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/author | "Fiorucci G."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/author | "Vannucchi S."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/author | "Vannucchi S."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/name | "J. Interferon Cytokine Res."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/name | "J. Interferon Cytokine Res."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/pages | "39-47"xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/pages | "39-47"xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/title | "IRF-1 as a negative regulator of cell proliferation."xsd:string |
http://purl.uniprot.org/citations/11846974 | http://purl.uniprot.org/core/title | "IRF-1 as a negative regulator of cell proliferation."xsd:string |