| http://purl.uniprot.org/citations/11846978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11846978 | http://www.w3.org/2000/01/rdf-schema#comment | "Maximal activation of murine infection-A4 (IFNA4) gene transcription following viral infection requires the presence of four cooperating DNA sequences (denoted A to D), which make up the virus responsive element VRE-A4. The B, C, and D modules, when tandemized, form binding sites for the virus-induced factor (VIF), a multiprotein complex that is detected early after viral infection in the nuclei of mouse L929 cells. We now demonstrate that IFN regulatory factor-3 (IRF-3) is a component of VIF and that VIF is different from the previously identified virus-activated complexes containing IRF-3 and coactivators of transcription, such as CREB binding protein (CBP) or p300. We also show that the C module is critical for both IRF-3-mediated and virus-induced transcription of the murine IFNA4 gene. Consistently, DNase I footprinting experiments and EMSA performed with increasing amounts of recombinant GST-IRF-3(DBD) fusion proteins demonstrate that cooperativity between the modules facilitate the binding of IRF-3 and recruitment of transcription coactivators on the IFNA4 promoter. These results indicate that VIF differentially recognizes the virus-responsive modules of VRE-A4 and further actualize our previous model concerning the differential expression of murine IFNA genes."xsd:string |
| http://purl.uniprot.org/citations/11846978 | http://purl.org/dc/terms/identifier | "doi:10.1089/107999002753452683"xsd:string |
| http://purl.uniprot.org/citations/11846978 | http://purl.uniprot.org/core/author | "Civas A."xsd:string |
| http://purl.uniprot.org/citations/11846978 | http://purl.uniprot.org/core/author | "Genin P."xsd:string |
| http://purl.uniprot.org/citations/11846978 | http://purl.uniprot.org/core/author | "Morin P."xsd:string |
| http://purl.uniprot.org/citations/11846978 | http://purl.uniprot.org/core/author | "Doly J."xsd:string |
| http://purl.uniprot.org/citations/11846978 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11846978 | http://purl.uniprot.org/core/name | "J Interferon Cytokine Res"xsd:string |
| http://purl.uniprot.org/citations/11846978 | http://purl.uniprot.org/core/pages | "77-86"xsd:string |
| http://purl.uniprot.org/citations/11846978 | http://purl.uniprot.org/core/title | "The virus-induced factor VIF differentially recognizes the virus-responsive modules of the mouse IFNA4 gene promoter."xsd:string |
| http://purl.uniprot.org/citations/11846978 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/11846978 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11846978 |
| http://purl.uniprot.org/citations/11846978 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11846978 |
| http://purl.uniprot.org/uniprot/#_Q540C2-mappedCitation-11846978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11846978 |
| http://purl.uniprot.org/uniprot/#_P07351-mappedCitation-11846978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11846978 |
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| http://purl.uniprot.org/uniprot/P07351 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11846978 |
| http://purl.uniprot.org/uniprot/Q540C2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11846978 |
| http://purl.uniprot.org/uniprot/Q91ZB3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11846978 |