| http://purl.uniprot.org/citations/11847115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11847115 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-myb proto-oncogene product (c-Myb) is a transcriptional activator. Vertebrate c-Myb is a key regulator of the G(1)/S transition in cell cycle, while Drosophila Myb (dMyb) is important for the G(2)/M transition. Here we report that dMyb induces expression of cyclin B, a critical regulator of the G(2)/M transition, in Drosophila eye imaginal disc. In the wild-type eye disc, dmyb mRNA was expressed in the stripes both anterior and posterior to the morphogenetic furrow. Ectopic expression of C-terminal-truncated dMyb in the eye disc caused ectopic expression of cyclin B and the rough eye phenotype. This rough eye phenotype correlated with prolonged M phase, caused by overexpression of cyclin B. Cyclin B expression was lost in dmyb-deficient clones. In Schneider cells, the activity of the cyclin B promoter was dramatically reduced by loss of dMyb using the RNA interference method. Mutations of the multiple AACNG sequences in the cyclin B promoter also abolished the promoter activity. These results indicate that dMyb regulates the G(2)/M transition by inducing cyclin B expression via binding to its promoter."xsd:string |
| http://purl.uniprot.org/citations/11847115 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/21.4.675"xsd:string |
| http://purl.uniprot.org/citations/11847115 | http://purl.uniprot.org/core/author | "Ishii S."xsd:string |
| http://purl.uniprot.org/citations/11847115 | http://purl.uniprot.org/core/author | "Okada M."xsd:string |
| http://purl.uniprot.org/citations/11847115 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/11847115 | http://purl.uniprot.org/core/author | "Akimaru H."xsd:string |
| http://purl.uniprot.org/citations/11847115 | http://purl.uniprot.org/core/author | "Hou D.X."xsd:string |
| http://purl.uniprot.org/citations/11847115 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11847115 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/11847115 | http://purl.uniprot.org/core/pages | "675-684"xsd:string |
| http://purl.uniprot.org/citations/11847115 | http://purl.uniprot.org/core/title | "Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc."xsd:string |
| http://purl.uniprot.org/citations/11847115 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/11847115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11847115 |
| http://purl.uniprot.org/citations/11847115 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11847115 |
| http://purl.uniprot.org/uniprot/P20439#attribution-CBE8080C6E389F9226E34E2DD42F0C03 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11847115 |
| http://purl.uniprot.org/uniprot/P04197#attribution-81B9A5A472C3FC1B3DBE4BA18F61ABB2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11847115 |
| http://purl.uniprot.org/uniprot/P04197#attribution-976894CDC3949FABDCFE4FF7A212241A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11847115 |
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| http://purl.uniprot.org/uniprot/#_C9QPI9-mappedCitation-11847115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11847115 |
| http://purl.uniprot.org/uniprot/#_P04197-mappedCitation-11847115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11847115 |
| http://purl.uniprot.org/uniprot/#_P10090-mappedCitation-11847115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11847115 |
| http://purl.uniprot.org/uniprot/#_O01368-mappedCitation-11847115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11847115 |
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| http://purl.uniprot.org/uniprot/#_M9PH39-mappedCitation-11847115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11847115 |