| http://purl.uniprot.org/citations/11853929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11853929 | http://www.w3.org/2000/01/rdf-schema#comment | "Starch-g-poly(acrylic acid) copolymers or grafted starches synthesized by 60Co irradiation or chemical modification and co-freeze-dried starch/poly(acrylic acid) mixtures were evaluated on their ex vivo bioadhesion capacity. The buccal absorption of testosterone from a bioadhesive tablet formulated with the grafted starches or starch/poly(acrylic acid) mixtures was investigated. The results were compared to a reference formulation (physical mixture of 5% Carbopol 974P and 95% Drum Dried Waxy Maize). Rice starch-based irradiated grafted starches showed the best bioadhesion results. Partial neutralization of the acrylic acid with Ca(2+) ions resulted in significantly higher bioadhesion values compared to the reference. Ca(2+) and Mg(2+) partially neutralized maltodextrin-based irradiated grafted starches showed significantly higher bioadhesion values compared to the reference formulation. The chemically modified grafted starches showed significantly higher adhesion force values than for the reference tablet. None of the co-freeze-dried starch/poly(acrylic acid) mixtures showed significantly higher bioadhesion results than the reference (Bonferroni test, P<0.05). A chemically modified grafted starch could sustain the 3 ng/ml plasma testosterone target concentration during +/-8 h (T(>3 ng/ml)). By lyophilization of a partially neutralized irradiated grafted starch, the in vivo adhesion time (22.0 +/-7.2 h) and the T(>3 ng/ml) (13.5 +/-1.3 h) could be increased. The absolute bioavailability of the lyophilized formulation approached the reference formulation. Some of the grafted starches showed to be promising buccal bioadhesive drug carriers for systemic delivery."xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0168-3659(01)00539-9"xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://purl.uniprot.org/core/author | "Richardson P."xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://purl.uniprot.org/core/author | "Tsai J."xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://purl.uniprot.org/core/author | "Remon J.P."xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://purl.uniprot.org/core/author | "Ameye D."xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://purl.uniprot.org/core/author | "Foreman P."xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://purl.uniprot.org/core/author | "Geresh S."xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://purl.uniprot.org/core/author | "Voorspoels J."xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11853929 | http://purl.uniprot.org/core/name | "J Control Release"xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://purl.uniprot.org/core/pages | "173-182"xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://purl.uniprot.org/core/title | "Ex vivo bioadhesion and in vivo testosterone bioavailability study of different bioadhesive formulations based on starch-g-poly(acrylic acid) copolymers and starch/poly(acrylic acid) mixtures."xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/11853929 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11853929 |
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