| http://purl.uniprot.org/citations/11854356 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11854356 | http://www.w3.org/2000/01/rdf-schema#comment | "Using a tumor model of spontaneously arising insulinomas expressing a defined tumor-associated antigen, we investigated whether tumor growth promotes cross-presentation and tolerance of tumor-specific T cells. We found that an advanced tumor burden enhanced cross-presentation of tumor-associated antigens to high avidity tumor-specific T cells, inducing T cell proliferation and limited effector function in vivo. However, contrary to other models, tumor-specific T cells were not tolerized despite a high tumor burden. In fact, in tumor-bearing mice, persistence and responsiveness of adoptively transferred tumor-specific T cells were enhanced. Accordingly, a potent T cell-mediated antitumor response could be elicited by intravenous administration of tumor-derived peptide and agonistic anti-CD40 antibody or viral immunization and reimmunization. Thus, in this model, tumor growth promotes activation of high avidity tumor-specific T cells instead of tolerance. Therefore, the host remains responsive to T cell immunotherapy."xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20010032"xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/author | "Murakami K."xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/author | "Nguyen L.T."xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/author | "Odermatt B."xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/author | "Ohashi P.S."xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/author | "Speiser D.E."xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/author | "Schoenberger S.P."xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/author | "Garza K.M."xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/author | "Elford A.R."xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/pages | "423-435"xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/title | "Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance."xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://purl.uniprot.org/core/volume | "195"xsd:string |
| http://purl.uniprot.org/citations/11854356 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11854356 |
| http://purl.uniprot.org/citations/11854356 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11854356 |
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