| http://purl.uniprot.org/citations/11854399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11854399 | http://www.w3.org/2000/01/rdf-schema#comment | "Particle ingestion by phagocytosis results from sequential rearrangements of the actin cytoskeleton and overlying membrane. To assemble a chronology of molecular events during phagosome formation and to examine the contributions of phosphoinositide 3-kinase (PI 3-kinase) to these dynamics, a method was developed for synchronizing Fcgamma receptor-mediated phagocytosis by murine macrophages. Erythrocytes opsonized with complement component C3bi were bound to macrophages at 37degrees C, a condition that does not favor particle phagocytosis. Addition of soluble anti-erythrocyte IgG resulted in rapid opsonization of the bound erythrocytes, followed by their immediate internalization via phagocytosis. Cellular content of F-actin, as measured by binding of rhodamine-phalloidin, increased transiently during phagocytosis, and this increase was not diminished by inhibitors of PI 3-kinase. Immunofluorescence localization of myosins in macrophages fixed at various times during phagocytosis indicated that myosins II and IXb were concentrated in early phagosomes, myosin IC increased later, and myosin V appeared after phagosome closure. Other cytoskeletal proteins showed similar variations in the timing of their appearance in phagosomes. The PI 3-kinase inhibitor wortmannin did not change the dynamics of PI 3-kinase or ezrin localization but prevented the loss of PAK1 from phagosomes. These results suggest that PI 3-kinase deactivates PAK1, and that this may be needed for phagosome closure."xsd:string |
| http://purl.uniprot.org/citations/11854399 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.01-05-0273"xsd:string |
| http://purl.uniprot.org/citations/11854399 | http://purl.uniprot.org/core/author | "Swanson J.A."xsd:string |
| http://purl.uniprot.org/citations/11854399 | http://purl.uniprot.org/core/author | "Bokoch G."xsd:string |
| http://purl.uniprot.org/citations/11854399 | http://purl.uniprot.org/core/author | "Diakonova M."xsd:string |
| http://purl.uniprot.org/citations/11854399 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11854399 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/11854399 | http://purl.uniprot.org/core/pages | "402-411"xsd:string |
| http://purl.uniprot.org/citations/11854399 | http://purl.uniprot.org/core/title | "Dynamics of cytoskeletal proteins during Fcgamma receptor-mediated phagocytosis in macrophages."xsd:string |
| http://purl.uniprot.org/citations/11854399 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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