| http://purl.uniprot.org/citations/11854508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11854508 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11854508 | http://www.w3.org/2000/01/rdf-schema#comment | "The innate immune system includes antimicrobial peptides that protect multicellular organisms from a diverse spectrum of microorganisms. beta-Defensins comprise one important family of mammalian antimicrobial peptides. The annotation of the human genome fails to reveal the expected diversity, and a recent query of the draft sequence with the blast search engine found only one new beta-defensin gene (DEFB3). To define better the beta-defensin gene family, we adopted a genomics approach that uses hmmer, a computational search tool based on hidden Markov models, in combination with blast. This strategy identified 28 new human and 43 new mouse beta-defensin genes in five syntenic chromosomal regions. Within each syntenic cluster, the gene sequences and organization were similar, suggesting each cluster pair arose from a common ancestor and was retained because of conserved functions. Preliminary analysis indicates that at least 26 of the predicted genes are transcribed. These results demonstrate the value of a genomewide search strategy to identify genes with conserved structural motifs. Discovery of these genes represents a new starting point for exploring the role of beta-defensins in innate immunity."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.042692699"xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.042692699"xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Casavant T.L."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Casavant T.L."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "McCray P.B. Jr."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "McCray P.B. Jr."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Schutte B.C."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Schutte B.C."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Bartlett J.A."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Bartlett J.A."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Welsh M.J."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Welsh M.J."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Jia H.P."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Jia H.P."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Mitros J.P."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Mitros J.P."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Walters J.D."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/author | "Walters J.D."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/11854508 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |