| http://purl.uniprot.org/citations/11854514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11854514 | http://www.w3.org/2000/01/rdf-schema#comment | "Studies of SOCS-1-deficient mice have implicated Socs-1 in the suppression of JAK-STAT (Janus tyrosine kinase-signal transducers and activators of transcription) signaling and T cell development. It has been suggested that the levels of Socs-1 protein may be regulated through the proteasome pathway. Here we show that Socs-1 interacts with members of the Pim family of serine/threonine kinases in thymocytes. Coexpression of the Pim kinases with Socs-1 results in phosphorylation and stabilization of the Socs-1 protein. The protein levels of Socs-1 are significantly reduced in the Pim-1(-/-), Pim-2(-/-) mice as compared with wild-type mice. Similar to Socs-1(-/-) mice, thymocytes from Pim-1(-/-), Pim-2(-/-) mice showed prolonged Stat6 phosphorylation upon IL-4 stimulation. These data suggest that the Pim kinases may regulate cytokine-induced JAK-STAT signaling through modulation of Socs-1 protein levels."xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.042035699"xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/author | "Vuong B.Q."xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/author | "Chen X.P."xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/author | "Fay S."xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/author | "Cohan V.L."xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/author | "Rothman P."xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/author | "Losman J.A."xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/author | "Nawijn M.C."xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/author | "Cowan S."xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/author | "Capece D."xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/author | "Donahue E."xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/pages | "2175-2180"xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/title | "Pim serine/threonine kinases regulate the stability of Socs-1 protein."xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/11854514 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11854514 |
| http://purl.uniprot.org/citations/11854514 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11854514 |
| http://purl.uniprot.org/uniprot/Q62070#attribution-B1B31E96C0A969DE9A2D74769481BC6F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11854514 |
| http://purl.uniprot.org/uniprot/O35716#attribution-B1B31E96C0A969DE9A2D74769481BC6F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11854514 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EGB5-mappedCitation-11854514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11854514 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EGX3-mappedCitation-11854514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11854514 |
| http://purl.uniprot.org/uniprot/#_F6WGR1-mappedCitation-11854514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11854514 |