| http://purl.uniprot.org/citations/11857333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11857333 | http://www.w3.org/2000/01/rdf-schema#comment | "NKG2D transmits stimulatory signals to natural killer cells and other hematopoietic cells, leading to enhanced proliferation, cytokine secretion and target killing. Murine and human NKG2D each recognize five known class I-related molecules with distinct primary structures. Here, we used surface plasmon resonance to examine the binding of murine NKG2D to its cognate ligands: RAE-1B6 (a newly described C57BL/6J variant of RAE-1), RAE-1 delta (common to BALB and C57BL6/J), and H60 (expressed in BALB, but not C57BL/6J). While RAE-1B6 and H60 display relatively high affinities for NKG2D with K(D) in the 20-30 nM range and k(off )in the 0.03s(-1) to 0.06s(-1) range (t(1/2) approximately 10-20s); the RAE-1 delta variant binds with a lower affinity: K(D) of approximately 750 nM. Furthermore, RAE-1 delta displays biphasic kinetics with dominant k(off) of approximately 0.2s(-1) (t(1/2) approximately 3s), partially explaining the lower affinity. Thus, H60 and RAE-1B6 bind NKG2D with almost identical kinetics while sharing only 20% amino acid sequence identity; whereas other RAE-1 molecules demonstrate faster dissociation and lower affinities than RAE-1B6 despite sharing 90% sequence identity. C57BL/6J mice, although not expressing the H60 gene product, retain a high-affinity ligand for NKG2D in the form of RAE-1B6."xsd:string |
| http://purl.uniprot.org/citations/11857333 | http://purl.org/dc/terms/identifier | "doi:10.1002/1521-4141(200203)32:3<597::aid-immu597>3.3.co;2-5"xsd:string |
| http://purl.uniprot.org/citations/11857333 | http://purl.uniprot.org/core/author | "Fremont D.H."xsd:string |
| http://purl.uniprot.org/citations/11857333 | http://purl.uniprot.org/core/author | "Ho E.L."xsd:string |
| http://purl.uniprot.org/citations/11857333 | http://purl.uniprot.org/core/author | "Yokoyama W."xsd:string |
| http://purl.uniprot.org/citations/11857333 | http://purl.uniprot.org/core/author | "Naidenko O.V."xsd:string |
| http://purl.uniprot.org/citations/11857333 | http://purl.uniprot.org/core/author | "Carayannopoulos L.N."xsd:string |
| http://purl.uniprot.org/citations/11857333 | http://purl.uniprot.org/core/author | "Kinder J."xsd:string |
| http://purl.uniprot.org/citations/11857333 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11857333 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11857333 | http://purl.uniprot.org/core/pages | "597-605"xsd:string |
| http://purl.uniprot.org/citations/11857333 | http://purl.uniprot.org/core/title | "Ligands for murine NKG2D display heterogeneous binding behavior."xsd:string |
| http://purl.uniprot.org/citations/11857333 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/11857333 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11857333 |
| http://purl.uniprot.org/citations/11857333 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11857333 |
| http://purl.uniprot.org/uniprot/#_O77968-mappedCitation-11857333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11857333 |
| http://purl.uniprot.org/uniprot/#_Q2TJJ6-mappedCitation-11857333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11857333 |
| http://purl.uniprot.org/uniprot/#_O54709-mappedCitation-11857333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11857333 |
| http://purl.uniprot.org/uniprot/#_O08603-mappedCitation-11857333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11857333 |
| http://purl.uniprot.org/uniprot/#_Q4FJM0-mappedCitation-11857333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11857333 |
| http://purl.uniprot.org/uniprot/#_Q3TCW7-mappedCitation-11857333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11857333 |
| http://purl.uniprot.org/uniprot/#_Q3TDL2-mappedCitation-11857333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11857333 |
| http://purl.uniprot.org/uniprot/#_Q3TDZ7-mappedCitation-11857333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11857333 |
| http://purl.uniprot.org/uniprot/#_Q3TM01-mappedCitation-11857333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11857333 |