| http://purl.uniprot.org/citations/11858172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11858172 | http://www.w3.org/2000/01/rdf-schema#comment | "The sphinganine-analog mycotoxins (SAMs) fumonisin B1 and AAL toxins are inhibitors of eukaryotic sphinganine N-acyltransferase in vitro. Treatment of eukaryotes with SAMs generally results in an accumulation of sphingoid base precursors and a depletion of complex sphingolipids. The asc,asc genotypes of tomato (Lycopersicon esculentum) and Nicotiana umbratica are sensitive to SAMs and host of the AAL toxin-producing fungus Alternaria alternata f. sp. lycopersici. Codominant insensitivity to SAMs in tomato is mediated by the Asc-1 gene, and sensitivity is associated with a frame-shift mutation present in asc-1. We investigated the function of Asc-1 in mediating insensitivity to SAMs and resistance to the fungus by overexpression of asc-1 and Asc-1. In this study, it is shown that overexpression of these genes did not lead to visual symptoms in tomato hairy roots and N. umbratica plants. Overexpression of asc-1 did not influence the (in)sensitivity to SAMs. Overexpression of Asc-1 in SAM-sensitive hairy roots and N. umbratica plants, however, mediated a high insensitivity to SAMs and resistance to plant infection by Alternaria alternata f. sp. lycopersici."xsd:string |
| http://purl.uniprot.org/citations/11858172 | http://purl.org/dc/terms/identifier | "doi:10.1094/mpmi.2002.15.1.35"xsd:string |
| http://purl.uniprot.org/citations/11858172 | http://purl.uniprot.org/core/author | "Brandwagt B.F."xsd:string |
| http://purl.uniprot.org/citations/11858172 | http://purl.uniprot.org/core/author | "Hille J."xsd:string |
| http://purl.uniprot.org/citations/11858172 | http://purl.uniprot.org/core/author | "Nijkamp H.J."xsd:string |
| http://purl.uniprot.org/citations/11858172 | http://purl.uniprot.org/core/author | "Kneppers T.J."xsd:string |
| http://purl.uniprot.org/citations/11858172 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11858172 | http://purl.uniprot.org/core/name | "Mol Plant Microbe Interact"xsd:string |
| http://purl.uniprot.org/citations/11858172 | http://purl.uniprot.org/core/pages | "35-42"xsd:string |
| http://purl.uniprot.org/citations/11858172 | http://purl.uniprot.org/core/title | "Overexpression of the tomato Asc-1 gene mediates high insensitivity to AAL toxins and fumonisin B1 in tomato hairy roots and confers resistance to Alternaria alternata f. sp. lycopersici in Nicotiana umbratica plants."xsd:string |
| http://purl.uniprot.org/citations/11858172 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/11858172 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11858172 |
| http://purl.uniprot.org/citations/11858172 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11858172 |
| http://purl.uniprot.org/uniprot/#_Q9M6A3-mappedCitation-11858172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11858172 |
| http://purl.uniprot.org/uniprot/Q9M6A3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11858172 |