| http://purl.uniprot.org/citations/11859139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11859139 | http://www.w3.org/2000/01/rdf-schema#comment | "Eosinophil infiltration into the esophagus occurs in a wide range of diseases; however, the underlying pathophysiological mechanisms involved are largely unknown. We now report that the Th2 cytokine, IL-5, is necessary and sufficient for the induction of eosinophil trafficking to the esophagus. We show that transgenic mice overexpressing IL-5 under the control of a T cell (CD2) or a small intestinal enterocyte (fatty acid-binding protein) promoter have markedly increased eosinophil numbers in the esophagus. For example, esophageal eosinophil levels are 1.9 +/- 0.9 and 121 +/-14 eosinophils/mm(2) in wild-type and CD2-IL-5-transgenic mice, respectively. Consistent with this effect being mediated by a systemic mechanism, pharmacological administration of IL-5 via a miniosmotic pump in the peritoneal cavity resulted in blood and esophageal eosinophilia. To examine the role of IL-5 in oral Ag-induced esophageal eosinophilia, eosinophilic esophagitis was induced by allergen exposure in IL-5-deficient and wild-type mice. Importantly, IL-5-deficient mice were resistant to eosinophilic esophagitis. Finally, we examined the role of eotaxin when IL-5 was overproduced in vivo. Esophageal eosinophil levels in CD2-IL-5-transgenic mice were found to decrease 15-fold in the absence of the eotaxin gene; however, esophageal eosinophil numbers in eotaxin-deficient IL-5-transgenic mice still remained higher than wild-type mice. In conclusion, these studies demonstrate a central role for IL-5 in inducing eosinophil trafficking to the esophagus."xsd:string |
| http://purl.uniprot.org/citations/11859139 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.168.5.2464"xsd:string |
| http://purl.uniprot.org/citations/11859139 | http://purl.uniprot.org/core/author | "Mishra A."xsd:string |
| http://purl.uniprot.org/citations/11859139 | http://purl.uniprot.org/core/author | "Rothenberg M.E."xsd:string |
| http://purl.uniprot.org/citations/11859139 | http://purl.uniprot.org/core/author | "Brandt E.B."xsd:string |
| http://purl.uniprot.org/citations/11859139 | http://purl.uniprot.org/core/author | "Hogan S.P."xsd:string |
| http://purl.uniprot.org/citations/11859139 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11859139 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11859139 | http://purl.uniprot.org/core/pages | "2464-2469"xsd:string |
| http://purl.uniprot.org/citations/11859139 | http://purl.uniprot.org/core/title | "IL-5 promotes eosinophil trafficking to the esophagus."xsd:string |
| http://purl.uniprot.org/citations/11859139 | http://purl.uniprot.org/core/volume | "168"xsd:string |
| http://purl.uniprot.org/citations/11859139 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11859139 |
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