| http://purl.uniprot.org/citations/11861555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11861555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11861555 | http://www.w3.org/2000/01/rdf-schema#comment | "The protein kinase Raf is an important signaling protein. Raf activation is initiated by an interaction with GTP-bound Ras, and Raf functions in signal transmission by phosphorylating and activating a mitogen-activated protein (MAP) kinase kinase named MEK. We identified 13 mutations in the Caenorhabditis elegans lin-45 raf gene by screening for hermaphrodites with abnormal vulval formation or germline function. Weak, intermediate, and strong loss-of-function or null mutations were isolated. The phenotype caused by the most severe mutations demonstrates that lin-45 is essential for larval viability, fertility, and the induction of vulval cell fates. The lin-45(null) phenotype is similar to the mek-2(null) and mpk-1(null) phenotypes, indicating that LIN-45, MEK-2, and MPK-1 ERK MAP kinase function in a predominantly linear signaling pathway. The lin-45 alleles include three missense mutations that affect the Ras-binding domain, three missense mutations that affect the protein kinase domain, two missense mutations that affect the C-terminal 14-3-3 binding domain, three nonsense mutations, and one small deletion. The analysis of the missense mutations indicates that Ras binding, 14-3-3-binding, and protein kinase activity are necessary for full Raf function and suggests that a 14-3-3 protein positively regulates Raf-mediated signaling during C. elegans development."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/160.2.481"xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.org/dc/terms/identifier | "doi:10.1093/genetics/160.2.481"xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/author | "Kornfeld K."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/author | "Kornfeld K."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/author | "Schedl T."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/author | "Schedl T."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/author | "Lambie E.J."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/author | "Lambie E.J."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/author | "Hsu V."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/author | "Hsu V."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/author | "Zobel C.L."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/author | "Zobel C.L."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/pages | "481-492"xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/pages | "481-492"xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates."xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/volume | "160"xsd:string |
| http://purl.uniprot.org/citations/11861555 | http://purl.uniprot.org/core/volume | "160"xsd:string |