| http://purl.uniprot.org/citations/11863370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11863370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11863370 | http://www.w3.org/2000/01/rdf-schema#comment | "We have cloned a basic helix-loop-helix (bHLH) factor gene, Bhlhb4, from a mouse beta-cell line. Fluorescence in situ hybridization (FISH) and genetic mapping place Bhlhb4 at the telomeric end of mouse chromosome 2 (H3-H4), syntenic to human chromosome 20q13. Based on phylogenetic analysis, BHLHB4 belongs to a new subgroup of bHLH factors including at least four previously identified mouse bHLH factors: BHLHB5, MIST1, OLIG1, OLIG2, and OLIG3. In the developing nervous system, Bhlhb4 was found to mark the dimesencephalic boundary, suggesting that Bhlhb4 may have a role in diencephalic regionalization. In the pancreas, Bhlhb4 is expressed in a transient fashion that suggests a role in the pancreatic endocrine cell lineage. Transfection experiments show that BHLHB4 can repress transcriptional activation mediated through the pancreatic beta-cell specific insulin promoter enhancer RIPE3. Together, these data suggest that BHLHB4 may modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types."xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.2002.6708"xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.org/dc/terms/identifier | "doi:10.1006/geno.2002.6708"xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/author | "Bramblett D.E."xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/author | "Bramblett D.E."xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/author | "Tsai M.-J."xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/author | "Tsai M.-J."xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/pages | "402-412"xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/pages | "402-412"xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/title | "BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary."xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/title | "BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary."xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/11863370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11863370 |
| http://purl.uniprot.org/citations/11863370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11863370 |