| http://purl.uniprot.org/citations/11864995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11864995 | http://www.w3.org/2000/01/rdf-schema#comment | "The nonreceptor tyrosine kinase encoded by the c-Abl gene has the unique feature of an F-actin binding domain (FABD). Purified c-Abl tyrosine kinase is inhibited by F-actin, and this inhibition can be relieved through mutation of its FABD. The c-Abl kinase is activated by physiological signals that also regulate the actin cytoskeleton. We show here that c-Abl stimulated the formation of actin microspikes in fibroblasts spreading on fibronectin. This function of c-Abl is dependent on kinase activity and is not shared by c-Src tyrosine kinase. The Abl-dependent F-actin microspikes occurred under conditions where the Rho-family GTPases were inhibited. The FABD-mutated c-Abl, which is active in detached fibroblasts, stimulated F-actin microspikes independent of cell attachment. Moreover, FABD-mutated c-Abl stimulated the formation of F-actin branches in neurites of rat embryonic cortical neurons. The reciprocal regulation between F-actin and the c-Abl tyrosine kinase may provide a self-limiting mechanism in the control of actin cytoskeleton dynamics."xsd:string |
| http://purl.uniprot.org/citations/11864995 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200110014"xsd:string |
| http://purl.uniprot.org/citations/11864995 | http://purl.uniprot.org/core/author | "Wang J.Y."xsd:string |
| http://purl.uniprot.org/citations/11864995 | http://purl.uniprot.org/core/author | "Hunter T."xsd:string |
| http://purl.uniprot.org/citations/11864995 | http://purl.uniprot.org/core/author | "Woodring P.J."xsd:string |
| http://purl.uniprot.org/citations/11864995 | http://purl.uniprot.org/core/author | "O'Leary D.D."xsd:string |
| http://purl.uniprot.org/citations/11864995 | http://purl.uniprot.org/core/author | "Litwack E.D."xsd:string |
| http://purl.uniprot.org/citations/11864995 | http://purl.uniprot.org/core/author | "Lucero G.R."xsd:string |
| http://purl.uniprot.org/citations/11864995 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11864995 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/11864995 | http://purl.uniprot.org/core/pages | "879-892"xsd:string |
| http://purl.uniprot.org/citations/11864995 | http://purl.uniprot.org/core/title | "Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension."xsd:string |
| http://purl.uniprot.org/citations/11864995 | http://purl.uniprot.org/core/volume | "156"xsd:string |
| http://purl.uniprot.org/citations/11864995 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11864995 |
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