| http://purl.uniprot.org/citations/11865310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11865310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11865310 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca(v)2.1 channels, which mediate P/Q-type Ca2+ currents, undergo Ca2+/calmodulin (CaM)-dependent inactivation and facilitation that can significantly alter synaptic efficacy. Here we report that the neuronal Ca2+-binding protein 1 (CaBP1) modulates Ca(v)2.1 channels in a manner that is markedly different from modulation by CaM. CaBP1 enhances inactivation, causes a depolarizing shift in the voltage dependence of activation, and does not support Ca2+-dependent facilitation of Ca(v)2.1 channels. These inhibitory effects of CaBP1 do not require Ca2+, but depend on the CaM-binding domain in the alpha1 subunit of Ca(v)2.1 channels (alpha12.1). CaBP1 binds to the CaM-binding domain, co-immunoprecipitates with alpha12.1 from transfected cells and brain extracts, and colocalizes with alpha12.1 in discrete microdomains of neurons in the hippocampus and cerebellum. Our results identify an interaction between Ca2+ channels and CaBP1 that may regulate Ca2+-dependent forms of synaptic plasticity by inhibiting Ca2+ influx into neurons."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn805"xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn805"xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/author | "Lee A."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/author | "Lee A."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/author | "Palczewski K."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/author | "Palczewski K."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/author | "Catterall W.A."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/author | "Catterall W.A."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/author | "Scheuer T."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/author | "Scheuer T."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/author | "Westenbroek R.E."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/author | "Westenbroek R.E."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/author | "Haeseleer F."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/author | "Haeseleer F."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/name | "Nat. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/name | "Nat. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/pages | "210-217"xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/pages | "210-217"xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/title | "Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1."xsd:string |
| http://purl.uniprot.org/citations/11865310 | http://purl.uniprot.org/core/title | "Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1."xsd:string |