| http://purl.uniprot.org/citations/11869684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11869684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11869684 | http://www.w3.org/2000/01/rdf-schema#comment | "Notch1 signaling drives T cell development at the expense of B cell development from a common precursor, an effect that is dependent on a C-terminal Notch1 transcriptional activation domain. The function of Deltex1, initially identified as a positive modulator of Notch function in a genetic screen in Drosophila, is poorly understood. We now demonstrate that, in contrast to Notch1, enforced expression of Deltex1 in hematopoietic progenitors results in B cell development at the expense of T cell development in fetal thymic organ culture and in vivo. Consistent with these effects, Deltex1 antagonizes Notch1 signaling in transcriptional reporter assays by inhibiting coactivator recruitment. These data suggest that a balance of inductive Notch1 signals and inhibitory signals mediated through Deltex1 and other modulators regulate T-B lineage commitment."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(02)00271-6"xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(02)00271-6"xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Rodriguez C."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Rodriguez C."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Pear W.S."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Pear W.S."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Allman D."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Allman D."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Aster J.C."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Aster J.C."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Patriub V."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Patriub V."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Weng A."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Weng A."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Bakkour S."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Bakkour S."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Izon D.J."xsd:string |
| http://purl.uniprot.org/citations/11869684 | http://purl.uniprot.org/core/author | "Izon D.J."xsd:string |