| http://purl.uniprot.org/citations/11869689 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11869689 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of the lymphoid system is dependent on the Ets family transcription factor PU.1. We demonstrate that PU.1(-/-) hematopoietic progenitors fail to express IL-7Ralpha transcripts. Promoter and chromatin crosslinking analyses suggest that PU.1 directly regulates transcription of the IL-7Ralpha gene. Retroviral transduction of IL-7Ralpha into PU.1(-/-) progenitors restores IL-7-dependent proliferation and induces, at low frequency, the generation of pro-B cells undergoing an apparently normal program of differentiation. Although the related factor Spi-B can substitute for PU.1 in early B cell development, it is not required. These results demonstrate that PU.1 functions to regulate early B cell development in part by controlling the expression of the IL-7Ralpha gene."xsd:string |
| http://purl.uniprot.org/citations/11869689 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(02)00269-8"xsd:string |
| http://purl.uniprot.org/citations/11869689 | http://purl.uniprot.org/core/author | "Singh H."xsd:string |
| http://purl.uniprot.org/citations/11869689 | http://purl.uniprot.org/core/author | "Lee H.J."xsd:string |
| http://purl.uniprot.org/citations/11869689 | http://purl.uniprot.org/core/author | "DeKoter R.P."xsd:string |
| http://purl.uniprot.org/citations/11869689 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11869689 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/11869689 | http://purl.uniprot.org/core/pages | "297-309"xsd:string |
| http://purl.uniprot.org/citations/11869689 | http://purl.uniprot.org/core/title | "PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors."xsd:string |
| http://purl.uniprot.org/citations/11869689 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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