| http://purl.uniprot.org/citations/11870626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11870626 | http://www.w3.org/2000/01/rdf-schema#comment | "Virus-like particles (VLP) induce efficient CTL responses although they do not carry any genetic information. Here, we analyzed MHC class I associated presentation of VLP-derived CTL-epitopes in vivo. After intradermal injection of VLP containing the immunodominant epitope (p33) of lymphocytic choriomeningitis virus (p33-VLP), presentation of peptide p33 in draining lymph nodes was largely restricted to CD8(-) skin-derived dendritic cells (DC). Surprisingly, and in contrast to findings with tumor cells, TAP1-deficient DC and macrophages mediated efficient cross-presentation of VLP-derived p33 in vivo and in vitro. However, the ability of TAP1-deficient DC to cross-present p33-VLP was reduced compared to wild-type DC, indicating that in DC, both TAP-dependent and TAP-independent pathways were operative. In contrast, macrophages cross-presented p33-VLP normally in the absence of TAP. The TAP-dependent pathway of cross-presentation is therefore confined to DC while both macrophages and DC harbor the TAP-independent pathway. In summary, the results show that VLP-derived epitopes are cross-presented by CD8(-) DC in vivo in a partial TAP-independent fashion and highlight important differences in the processing machinery of DC versus macrophages."xsd:string |
| http://purl.uniprot.org/citations/11870626 | http://purl.org/dc/terms/identifier | "doi:10.1002/1521-4141(200203)32:3<818::aid-immu818>3.0.co;2-u"xsd:string |
| http://purl.uniprot.org/citations/11870626 | http://purl.uniprot.org/core/author | "Bachmann M.F."xsd:string |
| http://purl.uniprot.org/citations/11870626 | http://purl.uniprot.org/core/author | "Ruedl C."xsd:string |
| http://purl.uniprot.org/citations/11870626 | http://purl.uniprot.org/core/author | "Bachi T."xsd:string |
| http://purl.uniprot.org/citations/11870626 | http://purl.uniprot.org/core/author | "Lechner F."xsd:string |
| http://purl.uniprot.org/citations/11870626 | http://purl.uniprot.org/core/author | "Storni T."xsd:string |
| http://purl.uniprot.org/citations/11870626 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11870626 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11870626 | http://purl.uniprot.org/core/pages | "818-825"xsd:string |
| http://purl.uniprot.org/citations/11870626 | http://purl.uniprot.org/core/title | "Cross-presentation of virus-like particles by skin-derived CD8(-) dendritic cells: a dispensable role for TAP."xsd:string |
| http://purl.uniprot.org/citations/11870626 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/11870626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11870626 |
| http://purl.uniprot.org/citations/11870626 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11870626 |
| http://purl.uniprot.org/uniprot/#_A0A068BER1-mappedCitation-11870626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11870626 |
| http://purl.uniprot.org/uniprot/#_F6QHF1-mappedCitation-11870626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11870626 |
| http://purl.uniprot.org/uniprot/#_Q3U543-mappedCitation-11870626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11870626 |
| http://purl.uniprot.org/uniprot/#_Q62428-mappedCitation-11870626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11870626 |
| http://purl.uniprot.org/uniprot/#_Q62429-mappedCitation-11870626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11870626 |
| http://purl.uniprot.org/uniprot/#_Q64333-mappedCitation-11870626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11870626 |
| http://purl.uniprot.org/uniprot/#_Q3U6V4-mappedCitation-11870626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11870626 |
| http://purl.uniprot.org/uniprot/#_P21958-mappedCitation-11870626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11870626 |
| http://purl.uniprot.org/uniprot/#_Q3TBA3-mappedCitation-11870626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11870626 |
| http://purl.uniprot.org/uniprot/#_Q78E61-mappedCitation-11870626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11870626 |