| http://purl.uniprot.org/citations/11875111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11875111 | http://www.w3.org/2000/01/rdf-schema#comment | "DAX-1 (NROB1) is an atypical member of the nuclear receptor family that is predominantly expressed in mammalian reproductive tissues. While a receptor function of DAX-1 remains enigmatic, previous work has indicated that DAX-1 inhibits the activity of the orphan receptor steroidogenic factor 1 and the estrogen receptors (ERs), presumably via direct occupation of the coactivator-binding surface and subsequent recruitment of additional corepressors. In vivo evidence points at a particular role of DAX-1 for the development and maintenance of male reproductive functions. In this study, we have identified the androgen receptor (AR) NR3C4 as a novel target for DAX-1. We show that DAX-1 potently inhibits ligand-dependent transcriptional activation as well as the interaction between the N- and C-terminal activation domains of AR. We provide evidence for direct interactions of the two receptors that involve the N-terminal repeat domain of DAX-1 and the C-terminal ligand-binding and activation domain of AR. Moreover, DAX-1, known to shuttle between the cytoplasm and the nucleus, is capable of relocalizing AR in both cellular compartments, suggesting that intracellular tethering is associated with DAX-1 inhibition. These results implicate novel inhibitory mechanisms of DAX-1 action with particular relevance for the modulation of androgen-dependent gene transcription in the male reproductive system."xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.org/dc/terms/identifier | "doi:10.1210/mend.16.3.0804"xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/author | "Gustafsson J.A."xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/author | "Holter E."xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/author | "Treuter E."xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/author | "Palvimo J.J."xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/author | "Kotaja N."xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/author | "Janne O.A."xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/author | "Strauss L."xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/author | "Makela S."xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/author | "Kietz S."xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/pages | "515-528"xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/title | "Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1."xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/11875111 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11875111 |
| http://purl.uniprot.org/citations/11875111 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11875111 |
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| http://purl.uniprot.org/uniprot/P51843#attribution-9087B33F065C6B1AE5E5CAFD8EE8A31F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11875111 |
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| http://purl.uniprot.org/uniprot/#_A0A218PFR0-mappedCitation-11875111 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11875111 |