Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11877042http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the mechanism of disordered proliferation of leukemic cells and the proliferation inhibition by the Fas death domain (FASDD) in human leukemia cell line Meg-01.

Methods

The chimerical receptors (Fas/190, Fas/130) were constructed by Fas cytoplasmic domain with the leukemic inhibitory factor (LIF) receptor subunits gp190 and gp130, another chimerical receptor was constructed by replacing the gp130 in Fas/130 with Fas death domain (FAS/130f). The chimerical receptors were separately expressed on the membrane of Meg-01, and activated with anti-Fas antibodies to induce the oligomerics of the cytoplasmic regions (190cyt-190cyt-190cyt, 130cyt-130cyt-130cyt or FASDD-FASDD-FASDD) for initiating the intracellular signal transduction. c-myc expression level was assayed by means of immunoblotting and immunobiochemistry.

Results

Increased c-myc expression and cell proliferation were observed in the group of Fas/130 as compared with the other two groups.

Conclusion

The cytoplasmic domain of gp130 might involve the induction of c-myc expression and the cell proliferation of Meg-01 cell. The Fas death domain may be a medium in the apoptosis induction against the effect of gp130."xsd:string
http://purl.uniprot.org/citations/11877042http://purl.uniprot.org/core/author"Liu H."xsd:string
http://purl.uniprot.org/citations/11877042http://purl.uniprot.org/core/author"Liu S."xsd:string
http://purl.uniprot.org/citations/11877042http://purl.uniprot.org/core/author"Tang S."xsd:string
http://purl.uniprot.org/citations/11877042http://purl.uniprot.org/core/author"Shan J."xsd:string
http://purl.uniprot.org/citations/11877042http://purl.uniprot.org/core/date"2001"xsd:gYear
http://purl.uniprot.org/citations/11877042http://purl.uniprot.org/core/name"Zhonghua Xue Ye Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/11877042http://purl.uniprot.org/core/pages"9-12"xsd:string
http://purl.uniprot.org/citations/11877042http://purl.uniprot.org/core/title"[Regulation of c-myc expression in leukemic cell line Meg-01 by the death domain of Fas gene]."xsd:string
http://purl.uniprot.org/citations/11877042http://purl.uniprot.org/core/volume"22"xsd:string
http://purl.uniprot.org/citations/11877042http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11877042
http://purl.uniprot.org/citations/11877042http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/11877042
http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11877042
http://purl.uniprot.org/uniprot/#_A0A0A0N0L2-mappedCitation-11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11877042
http://purl.uniprot.org/uniprot/#_A0A0A0N0L5-mappedCitation-11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11877042
http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11877042
http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11877042
http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11877042
http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11877042
http://purl.uniprot.org/uniprot/#_B3CJ88-mappedCitation-11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11877042
http://purl.uniprot.org/uniprot/#_B3CJB3-mappedCitation-11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11877042
http://purl.uniprot.org/uniprot/#_B3CJB8-mappedCitation-11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11877042
http://purl.uniprot.org/uniprot/#_B3CJ63-mappedCitation-11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11877042
http://purl.uniprot.org/uniprot/#_B3CJ64-mappedCitation-11877042http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11877042
▶