| http://purl.uniprot.org/citations/11882296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11882296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11882296 | http://www.w3.org/2000/01/rdf-schema#comment | "Kinase Suppressor of Ras (KSR) is a conserved protein that positively regulates Ras signaling and may function as a scaffold for Raf, MEK, and ERK. However, the precise role of KSR is not well understood, and some observations have suggested that KSR might act in a parallel pathway. In C. elegans, ksr-1 is only required for a specific Ras-mediated process (sex myoblast migration) and is a nonessential positive regulator of other Ras-mediated developmental events. We report the existence of a second C. elegans ksr gene, ksr-2, which is required for Ras-mediated signaling during germline meiotic progression and functions redundantly with ksr-1 during development of the excretory system, hermaphrodite vulva, and male spicules. Thus, while the ksr-1 and ksr-2 genes are individually required only for specific Ras-dependent processes, together these two genes appear necessary for most aspects of Ras-mediated signaling in C. elegans. The finding that ksr-2; ksr-1 double mutants have strong ras-like phenotypes and severely reduced or absent levels of diphosphorylated MPK-1 ERK strongly supports models where KSR acts to promote the activation or maintenance of the Raf/MEK/ERK kinase cascade."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(02)00690-5"xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(02)00690-5"xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/author | "Sundaram M.V."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/author | "Sundaram M.V."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/author | "Schedl T."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/author | "Schedl T."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/author | "Church D."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/author | "Church D."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/author | "Rocheleau C.E."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/author | "Rocheleau C.E."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/author | "Lambie E."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/author | "Lambie E."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/author | "Ohmachi M."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/author | "Ohmachi M."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/pages | "427-433"xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/pages | "427-433"xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/title | "C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/11882296 | http://purl.uniprot.org/core/title | "C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation."xsd:string |