| http://purl.uniprot.org/citations/11884139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11884139 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription of the murine interferon-A4 (IFN-A4) gene is mediated by a virus responsive element (VRE-A4) located in the promoter proximal [-120 to -43] region. VRE-A4 contains four DNA modules (A to D) which cooperate for maximal IFN-A4 activation following virus infection. The differential expression between the highly expressed IFN-A4 and the weakly inducible IFN-A11 gene promoters is essentially due to point mutations within the C and D modules of the virus-responsive element VRE-A11. We now demonstrate that in murine L929 and human 293 cells, transcription factors IRF-3 and IRF-7, which are potent activators of virus-induced type I IFN transcription, differentially affect IFN-A4 and IFN-A11 promoter activities. Using electrophoretic mobility shift assays and DNase I footprinting data, our studies demonstrate that the AB modules correspond to a preferential site for IRF-7, whereas the C module is preferentially recognized by IRF-3. Furthermore, transfection of reporter constructs driven by four copies of different GAAANN hexameric motifs found within VRE-A4 indicates that the NN residues of these hexameric sequences define the preferential binding sites for IRF-3 or IRF-7. Together, these experiments clarify the molecular basis for differential expression of IFN-A genes following virus infection by delineating the sequence requirements for IRF association with the virus responsive elements of the IFN-A genes."xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://purl.org/dc/terms/identifier | "doi:10.1006/jmbi.2001.5401"xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://purl.uniprot.org/core/author | "Hiscott J."xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://purl.uniprot.org/core/author | "Braganca J."xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://purl.uniprot.org/core/author | "Civas A."xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://purl.uniprot.org/core/author | "Morin P."xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://purl.uniprot.org/core/author | "Doly J."xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://purl.uniprot.org/core/author | "Bandu M.T."xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11884139 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://purl.uniprot.org/core/pages | "1009-1022"xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://purl.uniprot.org/core/title | "Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription."xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://purl.uniprot.org/core/volume | "316"xsd:string |
| http://purl.uniprot.org/citations/11884139 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11884139 |
| http://purl.uniprot.org/citations/11884139 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11884139 |
| http://purl.uniprot.org/uniprot/#_E2GIM5-mappedCitation-11884139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11884139 |
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| http://purl.uniprot.org/uniprot/#_A0A7R8C4Y5-mappedCitation-11884139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11884139 |
| http://purl.uniprot.org/uniprot/#_Q540C2-mappedCitation-11884139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11884139 |
| http://purl.uniprot.org/uniprot/#_Q14653-mappedCitation-11884139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11884139 |