| http://purl.uniprot.org/citations/11884374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11884374 | http://www.w3.org/2000/01/rdf-schema#comment | "This study demonstrates that caveolae, omega-shaped membrane invaginations, are involved in cardiac sodium channel regulation by a mechanism involving the alpha subunit of the stimulatory heterotrimeric G-protein, Galpha(s), via stimulation of the cell surface beta-adrenergic receptor. Stimulation of beta-adrenergic receptors with 10 micromol/L isoproterenol in the presence of a protein kinase A inhibitor increased the whole-cell sodium current by a "direct" cAMP-independent G-protein mechanism. The addition of antibodies against caveolin-3 to the cell's cytoplasm via the pipette solution abrogated this direct G protein-induced increase in sodium current, whereas antibodies to caveolin-1 or caveolin-2 did not. Voltage-gated sodium channel proteins were found to associate with caveolin-rich membranes obtained by detergent-free buoyant density separation. The purity of the caveolar membrane fraction was verified by Western blot analyses, which indicated that endoplasmic/sarcoplasmic reticulum, endosomal compartments, Golgi apparatus, clathrin-coated vesicles, and sarcolemmal membranes were excluded from the caveolin-rich membrane fraction. Additionally, the sodium channel was found to colocalize with caveolar membranes by immunoprecipitation, indirect immunofluorescence, and immunogold transmission electron microscopy. These results suggest that stimulation of beta-adrenergic receptors, and thereby Galpha(s), promotes the presentation of cardiac sodium channels associated with caveolar membranes to the sarcolemma."xsd:string |
| http://purl.uniprot.org/citations/11884374 | http://purl.org/dc/terms/identifier | "doi:10.1161/hh0402.105177"xsd:string |
| http://purl.uniprot.org/citations/11884374 | http://purl.uniprot.org/core/author | "Lu T."xsd:string |
| http://purl.uniprot.org/citations/11884374 | http://purl.uniprot.org/core/author | "Lee H.C."xsd:string |
| http://purl.uniprot.org/citations/11884374 | http://purl.uniprot.org/core/author | "Shibata E.F."xsd:string |
| http://purl.uniprot.org/citations/11884374 | http://purl.uniprot.org/core/author | "Yarbrough T.L."xsd:string |
| http://purl.uniprot.org/citations/11884374 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11884374 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/11884374 | http://purl.uniprot.org/core/pages | "443-449"xsd:string |
| http://purl.uniprot.org/citations/11884374 | http://purl.uniprot.org/core/title | "Localization of cardiac sodium channels in caveolin-rich membrane domains: regulation of sodium current amplitude."xsd:string |
| http://purl.uniprot.org/citations/11884374 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/11884374 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11884374 |
| http://purl.uniprot.org/citations/11884374 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11884374 |
| http://purl.uniprot.org/uniprot/P51638#attribution-6E7D8D91335973DB9623677197540F75 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/11884374 |
| http://purl.uniprot.org/uniprot/#_P51638-mappedCitation-11884374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11884374 |
| http://purl.uniprot.org/uniprot/P51638 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11884374 |