| http://purl.uniprot.org/citations/11884473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11884473 | http://www.w3.org/2000/01/rdf-schema#comment | "Intratracheal instillation of Sephadex particles is a convenient model for assessing the impact of potential anti-inflammatory compounds on lung eosinophilia thought to be a key feature in asthma pathophysiology. However, the underlying cellular and molecular mechanisms involved are poorly understood. We have studied the time course of Sephadex-induced lung eosinophilia, changes in pulmonary T cell numbers, and gene and protein expression as well as the immunological and pharmacological modulation of these inflammatory indices in the Sprague Dawley rat. Sephadex increased T cell numbers (including CD4(+) T cells) and evoked a pulmonary eosinophilia that was associated with an increase in gene/protein expression of the Th2-type cytokines IL-4, IL-5, and IL-13 and eotaxin in lung tissue. Sephadex instillation also induced airway hyperreactivity to acetylcholine and bradykinin. A neutralizing Ab (R73) against the alphabeta-TCR caused 54% depletion of total (CD2(+)) pulmonary T cells accompanied by a significant inhibition of IL-4, IL-13 and eotaxin gene expression together with suppression (65% inhibition) of eosinophils in lung tissue 24 h after Sephadex treatment. Sephadex-induced eosinophilia and Th2 cytokine gene and/or protein expression were sensitive to cyclosporin A and budesonide, compounds that inhibit T cell function, suggesting a pivotal role for T cells in orchestrating Sephadex-induced inflammation in this model."xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.168.6.3004"xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/author | "Pecoraro M."xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/author | "Foster M.L."xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/author | "Underwood S.L."xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/author | "Battram C.H."xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/author | "Belvisi M.G."xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/author | "Birrell M.A."xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/author | "Dabrowski D."xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/author | "Haddad e.l.-B."xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/author | "McCluskie K."xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/pages | "3004-3016"xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/title | "Critical role for T cells in Sephadex-induced airway inflammation: pharmacological and immunological characterization and molecular biomarker identification."xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://purl.uniprot.org/core/volume | "168"xsd:string |
| http://purl.uniprot.org/citations/11884473 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11884473 |
| http://purl.uniprot.org/citations/11884473 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11884473 |
| http://purl.uniprot.org/uniprot/#_Q08125-mappedCitation-11884473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11884473 |
| http://purl.uniprot.org/uniprot/#_Q9R2C9-mappedCitation-11884473 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11884473 |
| http://purl.uniprot.org/uniprot/Q08125 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11884473 |
| http://purl.uniprot.org/uniprot/Q9R2C9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11884473 |