| http://purl.uniprot.org/citations/11887186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11887186 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11887186 | http://www.w3.org/2000/01/rdf-schema#comment | "Little is known about how molecular motors bind to their vesicular cargo. Here we show that myosin-Va, an actin-based vesicle motor, binds to one of its cargoes, the melanosome, by interacting with a receptor-protein complex containing Rab27a and melanophilin, a postulated Rab27a effector. Rab27a binds to the melanosome first and then recruits melanophilin, which in turn recruits myosin-Va. Melanophilin creates this link by binding to Rab27a in a GTP-dependent fashion through its amino terminus, and to myosin-Va through its carboxy terminus. Moreover, this latter interaction, similar to the ability of myosin-Va to colocalize with melanosomes and influence their distribution in vivo, is absolutely dependent on the presence of exon-F, an alternatively spliced exon in the myosin-Va tail. These results provide the first molecular description of an organelle receptor for an actin-based motor, illustrate how alternate exon usage can be used to specify cargo, and further expand the functional repertoire of Rab GTPases and their effectors."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb760"xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb760"xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Hammer J.A. III"xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Hammer J.A. III"xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Rao K."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Rao K."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Sellers J.R."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Sellers J.R."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Wu X.S."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Wu X.S."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Matesic L.E."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/author | "Matesic L.E."xsd:string |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11887186 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |