| http://purl.uniprot.org/citations/11889128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11889128 | http://www.w3.org/2000/01/rdf-schema#comment | "Elastase/anti-elastase imbalance is a hallmark of emphysema, a chronic obstructive pulmonary disease associated with the rupture and inefficient repair of interstitial elastin. We report that neutrophil elastase (NE) at low physiologic concentrations, ranging from 35 nm to 1 microm, invokes transient, peaking at 15 min, activation of extracellular signal-regulated kinases 1 and 2 (ERK) in elastogenic lung fibroblasts. ERK activation is preceded by the release of soluble 25-26-kDa forms of epidermal growth factor (EGF) and transactivation of EGF receptor (EGFR) in NE-exposed cells. The stimulatory effect of NE on ERK is abrogated in the presence of anti-EGF-neutralizing antibodies, EGFR tyrosine kinase inhibitor (AG1478), and ERK kinase inhibitor (PD98059), as well as abolished in both EGFR-desensitized and endocytosis-arrested fibroblasts. Nuclear accumulation of activated ERK is associated with transient, peaking at 30 min, induction of c-Fos and sustained, observed at 24-48 h, decrease of tropoelastin mRNA levels in NE-challenged cells. Pretreatment of fibroblasts with AG1478 or PD98059 abrogates the NE-initiated tropoelastin mRNA suppression. We conclude that proteolytically released EGF signals directly via EGFR and ERK to down-regulate tropoelastin mRNA in NE-challenged lung fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/11889128 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m200243200"xsd:string |
| http://purl.uniprot.org/citations/11889128 | http://purl.uniprot.org/core/author | "Panchenko M.P."xsd:string |
| http://purl.uniprot.org/citations/11889128 | http://purl.uniprot.org/core/author | "Stone P.J."xsd:string |
| http://purl.uniprot.org/citations/11889128 | http://purl.uniprot.org/core/author | "Foster J.A."xsd:string |
| http://purl.uniprot.org/citations/11889128 | http://purl.uniprot.org/core/author | "Nugent M.A."xsd:string |
| http://purl.uniprot.org/citations/11889128 | http://purl.uniprot.org/core/author | "Panchenko M.V."xsd:string |
| http://purl.uniprot.org/citations/11889128 | http://purl.uniprot.org/core/author | "Carreras I."xsd:string |
| http://purl.uniprot.org/citations/11889128 | http://purl.uniprot.org/core/author | "DiCamillo S.J."xsd:string |
| http://purl.uniprot.org/citations/11889128 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11889128 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/11889128 | http://purl.uniprot.org/core/pages | "18938-18946"xsd:string |
| http://purl.uniprot.org/citations/11889128 | http://purl.uniprot.org/core/title | "Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/11889128 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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