| http://purl.uniprot.org/citations/11891332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11891332 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling via mitogen-activated protein kinases is implicated in heart failure induced by agonists for G protein-coupled receptors that act via the G protein Galphaq. However, this assertion relies heavily on pharmacological inhibitors and dominant-interfering proteins and not on gene deletion. Here, we show that endogenous cardiac MAPK/ERK kinase kinase-1 (MEKK1)/(MAP3K1), a mitogen-activated protein kinase kinase kinase, is activated by heart-restricted overexpression of Galphaq in mice. In cardiac myocytes derived from embryonic stem cells in culture, homozygous disruption of MEKK1 selectively impaired c-Jun N-terminal kinase activity in the absence or presence of phenlyephrine, a Galphaq-dependent agonist. Other terminal mitogen-activated protein kinases were unaffected. In mice, the absence of MEKK1 abolished the increase in cardiac mass, myocyte size, hypertrophy-associated atrial natriuretic factor induction, and c-Jun N-terminal kinase activation by Galphaq, and improved ventricular mechanical function. Thus, MEKK1 mediates cardiac hypertrophy induced by Galphaq in vivo and is a logical target for drug development in heart disease involving this pathway."xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.062453699"xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://purl.uniprot.org/core/author | "Minamino T."xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://purl.uniprot.org/core/author | "Terada N."xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://purl.uniprot.org/core/author | "Schneider M.D."xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://purl.uniprot.org/core/author | "Johnson G.L."xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://purl.uniprot.org/core/author | "Michael L.H."xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://purl.uniprot.org/core/author | "Taffet G.E."xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://purl.uniprot.org/core/author | "Yujiri T."xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11891332 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://purl.uniprot.org/core/pages | "3866-3871"xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://purl.uniprot.org/core/title | "MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq."xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/11891332 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11891332 |
| http://purl.uniprot.org/citations/11891332 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11891332 |
| http://purl.uniprot.org/uniprot/#_D3YVX9-mappedCitation-11891332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11891332 |
| http://purl.uniprot.org/uniprot/#_F8VQ72-mappedCitation-11891332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11891332 |
| http://purl.uniprot.org/uniprot/#_Q3UHH5-mappedCitation-11891332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11891332 |
| http://purl.uniprot.org/uniprot/#_P21279-mappedCitation-11891332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11891332 |
| http://purl.uniprot.org/uniprot/#_P53349-mappedCitation-11891332 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11891332 |
| http://purl.uniprot.org/uniprot/P21279 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11891332 |
| http://purl.uniprot.org/uniprot/P53349 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11891332 |
| http://purl.uniprot.org/uniprot/D3YVX9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11891332 |