| http://purl.uniprot.org/citations/11895777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11895777 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the Src family of kinases are abundant in platelets. Although their localization is known, their role(s) in platelet function are not well understood. Lyn is a Src-family kinase that participates in signal transduction pathways elicited by collagen-related peptide; it has also been implicated through biochemical studies in the regulation of von Willebrand factor signaling. Here, we provide evidence that Lyn plays a role in gamma-thrombin activation of platelets. Unlike the wild-type platelets, platelets from Lyn-deficient mice do not undergo irreversible aggregation, produce thromboxane A2, or secrete adenosine diphosphate in response to submaximal gamma-thrombin concentrations that cause secretion-dependent irreversible aggregation. Phosphorylation of Akt, a downstream effector of phosphatidylinositol 3-kinase, also requires a higher concentration of gamma-thrombin in Lyn-deficient platelets than in wild-type platelets. These findings demonstrate that Lyn signaling is required for thrombin induction of secretion-dependent platelet aggregation. Specifically, Lyn is required under these conditions to enable thrombin-induced TxA2 production and adenosine diphosphate secretion, necessary steps in secretion-dependent platelet aggregation."xsd:string |
| http://purl.uniprot.org/citations/11895777 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood.v99.7.2442"xsd:string |
| http://purl.uniprot.org/citations/11895777 | http://purl.uniprot.org/core/author | "Cho M.J."xsd:string |
| http://purl.uniprot.org/citations/11895777 | http://purl.uniprot.org/core/author | "Lowell C.A."xsd:string |
| http://purl.uniprot.org/citations/11895777 | http://purl.uniprot.org/core/author | "Gartner T.K."xsd:string |
| http://purl.uniprot.org/citations/11895777 | http://purl.uniprot.org/core/author | "Jackson C.W."xsd:string |
| http://purl.uniprot.org/citations/11895777 | http://purl.uniprot.org/core/author | "Pestina T.I."xsd:string |
| http://purl.uniprot.org/citations/11895777 | http://purl.uniprot.org/core/author | "Steward S.A."xsd:string |
| http://purl.uniprot.org/citations/11895777 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11895777 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/11895777 | http://purl.uniprot.org/core/pages | "2442-2447"xsd:string |
| http://purl.uniprot.org/citations/11895777 | http://purl.uniprot.org/core/title | "Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin."xsd:string |
| http://purl.uniprot.org/citations/11895777 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/11895777 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11895777 |
| http://purl.uniprot.org/citations/11895777 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11895777 |
| http://purl.uniprot.org/uniprot/#_P25911-mappedCitation-11895777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11895777 |
| http://purl.uniprot.org/uniprot/#_Q05DV0-mappedCitation-11895777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11895777 |
| http://purl.uniprot.org/uniprot/#_Q3TCS3-mappedCitation-11895777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11895777 |
| http://purl.uniprot.org/uniprot/#_Q3U6Q5-mappedCitation-11895777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11895777 |
| http://purl.uniprot.org/uniprot/#_Q8CEI0-mappedCitation-11895777 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11895777 |
| http://purl.uniprot.org/uniprot/Q8CEI0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11895777 |
| http://purl.uniprot.org/uniprot/P25911 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11895777 |
| http://purl.uniprot.org/uniprot/Q3TCS3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11895777 |
| http://purl.uniprot.org/uniprot/Q05DV0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/11895777 |