| http://purl.uniprot.org/citations/11895779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11895779 | http://www.w3.org/2000/01/rdf-schema#comment | "Antithrombin (AT) deficiency is an autosomal disorder associated with venous thromboembolism. However, a diagnosis of homozygous AT deficiency is seldom made. Most patients are heterozygous and have approximately 50% AT activities, and they are at higher risk for the development of thromboembolism. Through gene targeting we generated AT-deficient mice and previously reported that completely AT-deficient mice could not survive the prenatal period because of extensive thrombosis in the myocardium and liver sinusoids. In contrast, heterozygous AT-deficient mice with 50% AT activities have not shown spontaneous thromboembolic episodes. To demonstrate a thrombotic tendency in heterozygous AT deficiency, we challenged heterozygous AT-deficient mice (AT+/-mice) with the administration of lipopolysaccharide (LPS) or with restraint stress by immobilization. LPS injection markedly induced fibrin deposition in the kidney glomeruli, myocardium, and liver sinusoids in AT+/-mice compared with wild-type mice (AT+/+ mice). Restraint stress tests were performed by placing mice in 50-mL conical centrifuge tubes for 20 hours. Fibrin deposition was observed in the kidney of AT+/+ and AT+/- mice, but AT+/-mice exhibited more extensive fibrin deposition than AT+/+ mice. After prophylactic administration of human AT concentrates to increase plasma AT activities of AT+/-mice, LPS-induced fibrin deposition was effectively prevented. These results suggest that heterozygous AT deficiency is significantly associated with a tendency toward thrombosis formation in the kidney. The AT+/-mouse thus is a useful model for studying the effect of environmental or genetic risk factors on thrombogenesis."xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood.v99.7.2455"xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/author | "Ishiguro K."xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/author | "Nishimura M."xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/author | "Yamamoto K."xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/author | "Muramatsu T."xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/author | "Nakayama Y."xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/author | "Kojima T."xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/author | "Matsushita T."xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/author | "Kadomatsu K."xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/author | "Yanada M."xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/pages | "2455-2458"xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/title | "Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://purl.uniprot.org/core/volume | "99"xsd:string |
| http://purl.uniprot.org/citations/11895779 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11895779 |
| http://purl.uniprot.org/citations/11895779 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11895779 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWH7-mappedCitation-11895779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11895779 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX49-mappedCitation-11895779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11895779 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX70-mappedCitation-11895779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11895779 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX85-mappedCitation-11895779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11895779 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXS8-mappedCitation-11895779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11895779 |