| http://purl.uniprot.org/citations/11897624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11897624 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of the present study was to assess the role of endothelin (ET) in ischemia-reperfusion (I/R)-induced mucosal injury. Mucosal permeability ((51)Cr-EDTA clearance) and tissue myeloperoxidase (MPO) activity were significantly increased after 30 min of ischemia followed by 30 min of reperfusion. The I/R-induced increases in mucosal permeability and polymorphonuclear leukocyte (PMN) infiltration were significantly attenuated by pretreatments with ET(A) (BQ-485) and/or ET(B) (BQ-788) receptor antagonists. Monoclonal antibody (MAb) directed against intercellular adhesion molecule-1 (ICAM-1; MAb 1A29) and superoxide dismutase (SOD) pretreatments significantly attenuated the increased mucosal permeability and PMN infiltration in a similar manner as with ET receptor antagonists. Superior mesenteric artery blood flow was significantly reduced during the reperfusion period. Both ET receptor antagonists caused a significant rise in blood flow compared with an untreated I/R group. In conclusion, our data suggest that ET(A) and/or ET(B) receptors, ICAM-1, and superoxide play an important role in I/R-induced mucosal dysfunction and PMN infiltration. Furthermore, ET is involved in the pathogenesis of post-reperfusion-induced damage and beneficial effects of ET receptor antagonism are related to an improvement of disturbed blood flow during the reperfusion period."xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.2002.282.4.g647"xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/author | "Granger D.N."xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/author | "Ghandour S."xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/author | "Bozkurt A."xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/author | "Bilsel S."xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/author | "Cetinel S."xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/author | "Gulpinar M.A."xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/author | "Kurtel H."xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/author | "Moini H."xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/author | "Oktar B.K."xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/author | "Yegen B.C."xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/name | "Am J Physiol Gastrointest Liver Physiol"xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/pages | "G647-55"xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/title | "Endothelin receptor blockers reduce I/R-induced intestinal mucosal injury: role of blood flow."xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/11897624 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11897624 |
| http://purl.uniprot.org/citations/11897624 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11897624 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JSX5-mappedCitation-11897624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11897624 |
| http://purl.uniprot.org/uniprot/#_A1Y2B8-mappedCitation-11897624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11897624 |
| http://purl.uniprot.org/uniprot/#_A1Y2R7-mappedCitation-11897624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11897624 |
| http://purl.uniprot.org/uniprot/#_A1Y2R8-mappedCitation-11897624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11897624 |
| http://purl.uniprot.org/uniprot/#_A1Y2R9-mappedCitation-11897624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11897624 |