| http://purl.uniprot.org/citations/11897715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11897715 | http://www.w3.org/2000/01/rdf-schema#comment | "Steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF)-2 are homologous nuclear receptor coactivators. We have investigated their possible redundancy as thyroid hormone (TH) coactivators by measuring thyroid function in compound SRC-1 and TIF-2 knock out (KO) mice. Whereas SRC-1 KO (SRC-1(-/-)) mice are resistant to TH and SRC-1(+/-) are not, we now demonstrate that TIF-2 KO (TIF-2(-/-)) mice have normal thyroid function. Yet double heterozygous, SRC-1(+/-)/TIF-2(+/-) mice manifested resistance to TH of a similar degree as that in mice completely deficient in SRC-1. KO of both SRC-1 and TIF-2 resulted in marked increases of serum TH and thyrotropin concentrations. This work demonstrates gene dosage effect in nuclear coactivators manifesting as haploinsufficiency and functional redundancy of SRC-1 and TIF-2."xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://purl.org/dc/terms/identifier | "doi:10.1210/endo.143.4.8828"xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://purl.uniprot.org/core/author | "Chambon P."xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://purl.uniprot.org/core/author | "Refetoff S."xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://purl.uniprot.org/core/author | "Weiss R.E."xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://purl.uniprot.org/core/author | "O'Malley B.W."xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://purl.uniprot.org/core/author | "Gehin M."xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://purl.uniprot.org/core/author | "Sadow P.M."xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11897715 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://purl.uniprot.org/core/pages | "1554-1557"xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://purl.uniprot.org/core/title | "Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency."xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://purl.uniprot.org/core/volume | "143"xsd:string |
| http://purl.uniprot.org/citations/11897715 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11897715 |
| http://purl.uniprot.org/citations/11897715 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11897715 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7S6-mappedCitation-11897715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11897715 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P881-mappedCitation-11897715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11897715 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6K7-mappedCitation-11897715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11897715 |
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| http://purl.uniprot.org/uniprot/#_A0A1W2P7D7-mappedCitation-11897715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11897715 |
| http://purl.uniprot.org/uniprot/#_A6P3E3-mappedCitation-11897715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11897715 |
| http://purl.uniprot.org/uniprot/#_P70365-mappedCitation-11897715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11897715 |
| http://purl.uniprot.org/uniprot/#_D3Z4F6-mappedCitation-11897715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11897715 |