| http://purl.uniprot.org/citations/11904681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11904681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11904681 | http://www.w3.org/2000/01/rdf-schema#comment | "Unlike all other mammalian species, which have only one class I region, rat and mouse possess a second class I region on the centromeric side of the MHC. The mouse has class Ia genes in both the centromeric H2-K and the telomeric H2-D region, whereas the rat has class Ia genes only in the centromeric RT1.A region. Bat1 is the last gene of the class III region in the mouse, and H2-D was mapped 10 kb telomeric of Bat1. To determine whether the rat possesses an H2-D orthologue, we sequenced a cosmid clone that contains rat Bat1 and an adjacent class I gene, RT1.46 (l). Homology searches suggest a transition in the rat sequence with a proximal stretch containing Nfkbil1, ATP6G, and Bat1, which is homologous to the mouse H2-D region, and a more-distal stretch, which contains the class I gene and has many similarities to mouse H2-Q region sequences. Downstream of Bat1 is a sequence stretch with great similarity to intron 3 of H2-D, which is not present in any of the rat class I genes but is found in mouse H2-K, D-, and - Q region genes. Numerous repetitive elements indicate that the region is prone to repeat-mediated rearrangements. A putative H2-D orthologue may have been present at this location and lost by genomic rearrangements, leaving the short intronic sequence behind. The class I gene RT1.46 (l) has an open reading frame, but it is unlike H2-D due to a unique 5'UTR shared with H2-Q1 and Q2, the absence of the B2 SINE repeat characteristic of H2-D/L, and the apparent lack of surface expression. We conclude that at least the LEW rat (RT1 (l)) does not possess an H2-D orthologue."xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00251-001-0428-2"xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00251-001-0428-2"xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/author | "Fischer Lindahl K."xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/author | "Fischer Lindahl K."xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/author | "Lambracht-Washington D."xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/author | "Lambracht-Washington D."xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/pages | "1039-1046"xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/pages | "1039-1046"xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/title | "Does the rat have an H2-D orthologue next to Bat1?"xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/title | "Does the rat have an H2-D orthologue next to Bat1?"xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/11904681 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11904681 |
| http://purl.uniprot.org/citations/11904681 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11904681 |
| http://purl.uniprot.org/citations/11904681 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11904681 |
| http://purl.uniprot.org/citations/11904681 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11904681 |
| http://purl.uniprot.org/uniprot/Q63413 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11904681 |
| http://purl.uniprot.org/uniprot/F7EMR7 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11904681 |