| http://purl.uniprot.org/citations/11907260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11907260 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11907260 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we demonstrate that multiple tetraspanin (transmembrane 4 superfamily) proteins are palmitoylated, in either the Golgi or a post-Golgi compartment. Using CD151 as a model tetraspanin, we identified and mutated intracellular N-terminal and C-terminal cysteine palmitoylation sites. Simultaneous mutations of C11, C15, C242, and C243 (each to serine) eliminated >90% of CD151 palmitoylation. Notably, palmitoylation had minimal influence on the density of tetraspanin protein complexes, did not promote tetraspanin localization into detergent-resistant microdomains, and was not required for CD151-alpha 3 beta 1 integrin association. However, the CD151 tetra mutant showed markedly diminished associations with other cell surface proteins, including other transmembrane 4 superfamily proteins (CD9, CD63). Thus, palmitoylation may be critical for assembly of the large network of cell surface tetraspanin-protein interactions, sometimes called the "tetraspanin web." Also, compared with wild-type CD151, the tetra mutant was much more diffusely distributed and showed markedly diminished stability during biosynthesis. Finally, expression of the tetra-CD151 mutant profoundly altered alpha 3 integrin-deficient kidney epithelial cells, such that they converted from a dispersed, elongated morphology to an epithelium-like cobblestone clustering. These results point to novel biochemical and biological functions for tetraspanin palmitoylation."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.01-05-0275"xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.01-05-0275"xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Hemler M.E."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Hemler M.E."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Chen L.B."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Chen L.B."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Claas C."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Claas C."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Kraeft S.K."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Kraeft S.K."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Kreidberg J.A."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/author | "Kreidberg J.A."xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/pages | "767-781"xsd:string |
| http://purl.uniprot.org/citations/11907260 | http://purl.uniprot.org/core/pages | "767-781"xsd:string |