| http://purl.uniprot.org/citations/11908943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11908943 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice homozygous for the viable motheaten (Hcph(me-v)) mutation are deficient in SHP-1 protein-tyrosine phosphatase, resulting in severe systemic autoimmunity and immune dysfunction. A high percentage of B-cells in viable motheaten mice express the cell surface glycoprotein CD5, in contrast to wild type mice that express CD5 on only a small percentage of B-cells. CD5(+) B-cells have been associated with autoantibody production. To determine the role of CD5 in the development of the inflammatory disease in me(v)/ me(v) mice, we created a stock of CD5(null)me(v)/ me(v) mice. The longevity of CD5(null)me(v)/ me(v) mice was increased 69% in comparison to me(v)/ me(v) mice on a similar (B6;129) background. The increased lifespan was associated with a marked reduction in pulmonary inflammation. Flow cytometry analysis of spleen cells from CD5(null)me(v)/ me(v) mice at 9-12 weeks of age revealed significant decreases in percentages of IgM/B220 double positive B-cells, Mac-1/Gr-1 double positive cells and CD4(+) T-cells compared with me(v)/ me(v) mice. CD5(null)me(v)/ me(v) mice also had significantly lower serum IgM levels in comparison to me(v)/ me(v) mice. Study of CD5(null)me(v)/ me(v) mice may provide further insight into the role of CD5 in cell signaling and may help explain the observed association of CD5(+) B-cells with autoimmune disease."xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.org/dc/terms/identifier | "doi:10.1006/jaut.2001.0570"xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/author | "Yi T."xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/author | "Lyons B.L."xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/author | "Shultz L.D."xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/author | "Sundberg J.P."xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/author | "Lang P.A."xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/author | "Burzenski L."xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/author | "Lynes M.A."xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/author | "Joliat M.J."xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/name | "J Autoimmun"xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/pages | "105-117"xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/title | "Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice."xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/11908943 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11908943 |
| http://purl.uniprot.org/citations/11908943 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11908943 |
| http://purl.uniprot.org/uniprot/#_A0A494B9V0-mappedCitation-11908943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11908943 |
| http://purl.uniprot.org/uniprot/#_A0A494BB49-mappedCitation-11908943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11908943 |
| http://purl.uniprot.org/uniprot/#_G3UWU7-mappedCitation-11908943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11908943 |
| http://purl.uniprot.org/uniprot/#_G3UZU6-mappedCitation-11908943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11908943 |
| http://purl.uniprot.org/uniprot/#_G3UYY5-mappedCitation-11908943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11908943 |
| http://purl.uniprot.org/uniprot/#_G3UXM2-mappedCitation-11908943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11908943 |
| http://purl.uniprot.org/uniprot/#_P13379-mappedCitation-11908943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11908943 |