| http://purl.uniprot.org/citations/11909953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11909953 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11909953 | http://www.w3.org/2000/01/rdf-schema#comment | "Cripto-1 (CR-1), an epidermal growth factor-CFC (EGF-CFC) family member, has a demonstrated role in embryogenesis and mammary gland development and is overexpressed in several human tumors. Recently, EGF-CFC proteins were implicated as essential signaling cofactors for Nodal, a transforming growth factor beta family member whose expression has previously been defined as embryo specific. To identify a receptor for CR-1, a human brain cDNA phage display library was screened using CR-1 protein as bait. Phage inserts with identity to ALK4, a type I serine/threonine kinase receptor for Activin, were identified. CR-1 binds to cell surface ALK4 expressed on mammalian epithelial cells in fluorescence-activated cell sorter analysis, as well as by coimmunoprecipitation. Nodal is coexpressed with mouse Cr-1 in the mammary gland, and CR-1 can phosphorylate the transcription factor Smad-2 in EpH-4 mammary epithelial cells only in the presence of Nodal and ALK4. In contrast, CR-1 stimulation of mitogen-activated protein kinase and AKT in these cells is independent of Nodal and ALK4, suggesting that CR-1 may modulate different signaling pathways to mediate its different functional roles."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.8.2586-2597.2002"xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.8.2586-2597.2002"xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Khan N."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Khan N."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Williams K.P."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Williams K.P."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Adkins H.B."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Adkins H.B."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Bianco C."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Bianco C."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "De Luca A."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "De Luca A."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Ebert A."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Ebert A."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Kenney N."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Kenney N."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Normanno N."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Normanno N."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Salomon D.S."xsd:string |
| http://purl.uniprot.org/citations/11909953 | http://purl.uniprot.org/core/author | "Salomon D.S."xsd:string |