| http://purl.uniprot.org/citations/11909979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11909979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11909979 | http://www.w3.org/2000/01/rdf-schema#comment | "Using mouse knockouts for mitogen- and stress-activated protein kinase 1 (MSK1) and MSK2 and a double knockout of both MSK1 and MSK2, we show that these protein kinases are required for the stress-induced phosphorylation of transcription factors CREB and ATF1 in primary embryonic fibroblasts. In contrast mitogen-induced phosphorylation of CREB and ATF1 is greatly reduced but not totally abolished. The mitogen- and stress-induced phosphorylation of CREB at Ser133 has been linked to the transcription of several immediate early genes, including c-fos, junB, and egr1. The knockout of both MSK1 and MSK2 resulted in a 50% reduction in c-fos and junB gene transcription in response to anisomycin or UV-C radiation but only a small reduction in response to tetradecanoyl phorbol acetate or epidermal growth factor in fibroblasts. The transcription of egr1 in response to both mitogenic and stress stimuli, as well as stress-induced apoptosis, was unaffected in the MSK1/MSK2 double knockout."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.8.2871-2881.2002"xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.22.8.2871-2881.2002"xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/author | "Cohen P."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/author | "Cohen P."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/author | "Foster J.M."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/author | "Foster J.M."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/author | "Arthur J.S."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/author | "Arthur J.S."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/author | "Wiggin G.R."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/author | "Wiggin G.R."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/author | "Murray-Tait V."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/author | "Murray-Tait V."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/author | "Soloaga A."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/author | "Soloaga A."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/pages | "2871-2881"xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/pages | "2871-2881"xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/title | "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/11909979 | http://purl.uniprot.org/core/title | "MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts."xsd:string |