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http://purl.uniprot.org/citations/11912443http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11912443http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

The pathogenesis of 46 XX true hermaphroditism is uncertain and the role of the SRY gene in ovotestis development has not been thoroughly evaluated. We ascertained the presence of the SRY gene and SRY protein in the ovotestis.

Materials and methods

We evaluated 8 ovotestes by cytogenetic analysis of fibroblast cell culture and analysis of gonadal tissue by polymerase chain reaction to detect the SRY gene and by immunohistochemistry with a monoclonal antibody to human recombinant SRY protein.

Results

Fibroblast culture of the ovotestes demonstrated a 46XX karyotype. By polymerase chain reaction all 8 ovotestes demonstrated the SRY gene at low levels. By immunohistochemistry SRY protein was detected in all ovotestes, predominantly in Sertoli and germ cells.

Conclusions

The SRY gene has a role in ovotestis genesis. Mosaicism with a Y bearing cell line in the gonad is a possible explanation and further study is warranted."xsd:string
http://purl.uniprot.org/citations/11912443http://purl.org/dc/terms/identifier"doi:10.1097/00005392-200204000-00088"xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/author"Guillen-Navarro E."xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/author"McElreavey K."xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/author"Oddoux C."xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/author"Ostrer H."xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/author"Clarke V."xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/author"Sarafoglou K."xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/author"Yee H."xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/author"Craver R."xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/author"Ortenberg J."xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/author"Salas-Cortes L."xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/name"J Urol"xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/pages"1828-1831"xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/title"SRY gene expression in the ovotestes of XX true hermaphrodites."xsd:string
http://purl.uniprot.org/citations/11912443http://purl.uniprot.org/core/volume"167"xsd:string
http://purl.uniprot.org/citations/11912443http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/11912443
http://purl.uniprot.org/citations/11912443http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/11912443
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http://purl.uniprot.org/uniprot/#_D0VTX1-mappedCitation-11912443http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11912443
http://purl.uniprot.org/uniprot/#_D0VTX2-mappedCitation-11912443http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11912443
http://purl.uniprot.org/uniprot/#_D0VTX3-mappedCitation-11912443http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11912443
http://purl.uniprot.org/uniprot/#_D1H0M5-mappedCitation-11912443http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/11912443
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