| http://purl.uniprot.org/citations/11919285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11919285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11919285 | http://www.w3.org/2000/01/rdf-schema#comment | "Diversifying selection drives the rapid differentiation of gene sequences and is one of the main forces behind adaptive evolution. Most genes known to be shaped by diversifying selection are those involved in host-pathogen or male-female interactions characterized as molecular "arms races." Here we report the unexpected detection of diversifying selection in the evolution of a tumor-growth promoter, angiogenin (ANG). A comparison among 11 primate species demonstrates that ANG has a significantly higher rate of nucleotide substitution at nonsynonymous sites than at synonymous sites, a hallmark of positive selection acting at the molecular level. Furthermore, we observed significant charge diversity at the molecular surface, suggesting the presence of selective pressures in the microenvironment of ANG, including its binding molecules. A population survey of ANG in chimpanzees, however, reveals no polymorphism, which may have resulted from a recent selective sweep of a charge-altering substitution in chimpanzee evolution. Functional assays of recombinant ANGs from the human and owl monkey indicate that primate ANGs retain angiogenic activity despite rapid evolution. Our study, together with findings of similar selection in the primate breast cancer suppressor gene, BRCA1, reveals an intriguing phenomenon of unusual selective pressures on, and adaptive evolution of, cancer-related genes in primate evolution."xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.org/dc/terms/identifier | "doi:10.1093/oxfordjournals.molbev.a004099"xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.org/dc/terms/identifier | "doi:10.1093/oxfordjournals.molbev.a004099"xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/author | "Rosenberg H.F."xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/author | "Rosenberg H.F."xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/name | "Mol. Biol. Evol."xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/name | "Mol. Biol. Evol."xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/pages | "438-445"xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/pages | "438-445"xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/title | "Diversifying selection of the tumor-growth promoter angiogenin in primate evolution."xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/title | "Diversifying selection of the tumor-growth promoter angiogenin in primate evolution."xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/11919285 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11919285 |
| http://purl.uniprot.org/citations/11919285 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11919285 |
| http://purl.uniprot.org/citations/11919285 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11919285 |
| http://purl.uniprot.org/citations/11919285 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11919285 |
| http://purl.uniprot.org/uniprot/Q8WN63 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11919285 |
| http://purl.uniprot.org/uniprot/Q8WME8 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/11919285 |