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http://purl.uniprot.org/citations/11920573http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11920573http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/11920573http://www.w3.org/2000/01/rdf-schema#comment"TAPASIN, a V-C1 (variable-constant) immunoglobulin superfamily (IgSF) molecule that links MHC class I molecules to the transporter associated with antigen processing (TAP) in the endoplasmic reticulum (ER) is encoded by the TAPBP gene, located near to the MHC at 6p21.3. A related gene was identified at chromosome position 12p13.3 between the CD27 and VAMP1 genes near a group of MHC-paralogous loci. The gene, which we have called TAPBP-R (R for related), also encodes a member of the IgSF, TAPASIN-R. Its putative product contains similar structural motifs to TAPASIN, with some marked differences, especially in the V domain, transmembrane and cytoplasmic regions. By using the mouse ortholog to screen tissue, we revealed that the TAPBP-R gene was broadly expressed. Sub-cellular localization showed that the bulk of TAPASIN-R is located within the ER but biotinylation experiments were consistent with some expression at thecell surface. TAPASIN-R lacks an obvious ER retention signal. The function of TAPASIN-R will be of interest in regards to the evolution of the immune system as well as antigen processing."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.org/dc/terms/identifier"doi:10.1002/1521-4141(200204)32:4<1059::aid-immu1059>3.0.co;2-g"xsd:string
http://purl.uniprot.org/citations/11920573http://purl.org/dc/terms/identifier"doi:10.1002/1521-4141(200204)32:4<1059::aid-immu1059>3.0.co;2-g"xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/author"Stephens R."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/author"Stephens R."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/author"Trowsdale J."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/author"Trowsdale J."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/author"Du Pasquier L."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/author"Du Pasquier L."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/author"Freeman T."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/author"Freeman T."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/author"Lindquist J.A."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/author"Lindquist J.A."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/author"Teng M.S."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/author"Teng M.S."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/name"Eur. J. Immunol."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/name"Eur. J. Immunol."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/pages"1059-1068"xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/pages"1059-1068"xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/title"A human TAPBP (TAPASIN)-related gene, TAPBP-R."xsd:string
http://purl.uniprot.org/citations/11920573http://purl.uniprot.org/core/title"A human TAPBP (TAPASIN)-related gene, TAPBP-R."xsd:string