| http://purl.uniprot.org/citations/11923478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/11923478 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiotensin II, a potent vasoactive peptide produced by proteolysis of the angiotensinogen (AGT) prohormone, plays a critical role in cardiovascular homeostasis. Recently we showed that IL-6 induces human (h)AGT transcription by activating the signal transducers and activators of transcription (STATs). Here we investigated the role of the coactivator p300/cAMP response element binding protein-binding protein (CBP) in STAT3-mediated hAGT gene expression. Overexpression of adenovirus 12S E1A, which binds and inactivates p300/CBP, strongly inhibited basal and stimulated hAGT transcription, whereas a mutant E1A defective in binding p300/CBP did not. Conversely, ectopic expression of p300 and CBP potentiated inducible hAGT promoter activity. Coimmunoprecipitation assays revealed STAT3-p300 interaction upon IL-6 stimulation. The STAT3-p300 association requires the STAT3 C-terminal transactivation domain, as STAT3 deleted of transactivation functions as a dominant-negative inhibitor and does not associate with p300/CBP. The observation that IL-6 stimulation increases histone H4 acetylation of the endogenous hAGT promoter, and expression of p300 deficient in histone acetyltransferase activity down-regulates hAGT promoter activity both suggest that p300 histone acetyltransferase activity is required for hAGT expression. Finally, treatment of HepG2 cells with a histone deacetylase inhibitor increased the hAGT mRNA abundance by 2-to 3-fold. Taken together, our results indicate that IL-6-inducible expression of the hAGT promoter is mediated by physical association of the COOH terminus of STAT3 with p300/CBP, the recruitment of which targets histone acetylation and results in chromatin remodeling."xsd:string |
| http://purl.uniprot.org/citations/11923478 | http://purl.org/dc/terms/identifier | "doi:10.1210/mend.16.4.0811"xsd:string |
| http://purl.uniprot.org/citations/11923478 | http://purl.uniprot.org/core/author | "Lu M."xsd:string |
| http://purl.uniprot.org/citations/11923478 | http://purl.uniprot.org/core/author | "Ray S."xsd:string |
| http://purl.uniprot.org/citations/11923478 | http://purl.uniprot.org/core/author | "Brasier A.R."xsd:string |
| http://purl.uniprot.org/citations/11923478 | http://purl.uniprot.org/core/author | "Sherman C.T."xsd:string |
| http://purl.uniprot.org/citations/11923478 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/11923478 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/11923478 | http://purl.uniprot.org/core/pages | "824-836"xsd:string |
| http://purl.uniprot.org/citations/11923478 | http://purl.uniprot.org/core/title | "Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300/cAMP response element binding protein-binding protein coactivator recruitment and histone acetyltransferase activity."xsd:string |
| http://purl.uniprot.org/citations/11923478 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/11923478 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/11923478 |
| http://purl.uniprot.org/citations/11923478 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/11923478 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V395-mappedCitation-11923478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11923478 |
| http://purl.uniprot.org/uniprot/#_B5A210-mappedCitation-11923478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11923478 |
| http://purl.uniprot.org/uniprot/#_B5A211-mappedCitation-11923478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11923478 |
| http://purl.uniprot.org/uniprot/#_B5A212-mappedCitation-11923478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11923478 |
| http://purl.uniprot.org/uniprot/#_B5A213-mappedCitation-11923478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11923478 |
| http://purl.uniprot.org/uniprot/#_B5A214-mappedCitation-11923478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11923478 |
| http://purl.uniprot.org/uniprot/#_B5A215-mappedCitation-11923478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11923478 |
| http://purl.uniprot.org/uniprot/#_B5A216-mappedCitation-11923478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11923478 |
| http://purl.uniprot.org/uniprot/#_B5A217-mappedCitation-11923478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11923478 |
| http://purl.uniprot.org/uniprot/#_B5A218-mappedCitation-11923478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11923478 |
| http://purl.uniprot.org/uniprot/#_B5A219-mappedCitation-11923478 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/11923478 |